Hostname: page-component-7c8c6479df-p566r Total loading time: 0 Render date: 2024-03-30T00:52:06.966Z Has data issue: false hasContentIssue false

Annual and seasonal variations in the prevalence of congenital cardiac malformations in live-born infants

Published online by Cambridge University Press:  19 August 2008

Milan Samánek*
Affiliation:
From the Kardiocentrum, University Hospital Motol, Prague
Zdenek Slavík
Affiliation:
From the Kardiocentrum, University Hospital Motol, Prague
Miroslav Krejcir
Affiliation:
From the Kardiocentrum, University Hospital Motol, Prague
*
Prof. Dr. Milan ŠamánekKardiocentrum, University Hospital, Motol, 150 18 Prague 5, Czechoslovakia

Summary

The annual and seasonal distribution of the prevalence of congenital cardiac malformations was calculated in 664,218 infants born from 1977 to 1984 in Bohemia (population of 6.3 million). All children who died were autopsied and those confirmed as having a malformation of the heart were included in our series. In total, 4,409 infants (6.64/1,000 live-births) were born with a cardiac defect. Annual variations were insignificant. The prevalence rate of cardiac malformations at birth was highest in October and lowest in December, June and July. It was not modified by differences in the birthrate. The peak of the prevalence coincided with the epidemics of influenza in early pregnancy. A nonuniform seasonal variation was found in individual forms of congenital malformations of the heart, indicating their possible etiological heterogeneity.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 1992

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Samánek, M, SlavIk, Z. Congenital heart disease-incidence, seasonal and regional differences. Acta Univ Carol Med. [In press 1991]Google Scholar
2.Anderson, RC, Lillehei, CW, Lester, RG. Corrected transposi tion of the great vessels of the heart. Pediatrics 1957; 20: 625646.Google Scholar
3.Campbell, M. Causes of malformation of the heart. Brit Med J 1965; 2: 895904.Google Scholar
4.Landtman, B. Epidemiological aspects of congenital heart diseases. Acta Ped Scand 1965; 54: 467473.Google Scholar
5.Miettinen, OS, Reiner, ML, Nadas, AS, Seasonal incidence of coarctation of the aorta. Brit Heart J 1970; 32: 103107.Google Scholar
6.Rothman, KJ, Fyler, DC. Seasonal occurrence of complex ventricular septal defect. Lancet 1974; 2: 194197.Google Scholar
7.Bound, JP, Logan, WFWE. Incidence of congenital heart disease in Blackpool 1957–1971. Brit Heart J 1977; 39: 445450.Google Scholar
8.Feldt, JH, Avasthey, P, Yoshimasu, F, Kurland, LT, Titus, JI. Incidence of congenital heart disease in children born to residents of Olmsted County, Minnesota. 1950–1961. Mayo Clin Proc 1971; 46: 794799.Google Scholar
9.Kenna, AP, Smithells, RW, Fielding, OW. Congenital heart disease in Liverpool 1960–1969. Quart J Med 1975; 44: 1744.Google Scholar
10.Samánek, M, Slavik, Z, Zborilová, B, Hrobonová, V, VorIsková, M, Skovranek, J. Prevalence, treatment and outcome of heart disease in live-born children. Pediatr Cardiol 1980; 10: 205211.Google Scholar
11.Samánek, M, Goetzová, , Benesová, D. Distribution of congenital heart malformation in an autopsied child population. Int J Cardiol 1985; 8: 235248.Google Scholar
12.Miao, CHY, Zuberbuhler, IS, Zuberbuhler, JR. Prevalence of congenital anomalies at high altitude. J Amer Coll Cardiol 1988; 12: 224228.Google Scholar
13.Edwards, JH. Seasonal incidence of congenital disease in Birmingham. Ann Hum Genet 1961; 25: 8993.Google Scholar
14.Rothman, KJ, Fyler, DC. Association of congenital heart defects with season and population density. Teratology 1976; 13: 2934.Google Scholar
15.Polani, PE, Campbell, M. Factors in the causation of persistent ductus arteriosis.. Ann Hum Genet 1960; 24: 343.Google Scholar