Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-23T23:37:55.363Z Has data issue: false hasContentIssue false

Differential diagnosis of adolescent and adult pervasive developmental disorders/autism spectrum disorders (PDD/ASD): a not uncommon diagnostic dilemma

Published online by Cambridge University Press:  13 June 2014

Michael Fitzgerald*
Affiliation:
Trinity College, Dublin 2, Ireland.

Extract

The failure to recognise the pervasive developmental disorders/autism spectrum disorders is probably not uncommon in adult psychiatry. Indeed some of the treatment-resistant chronic mental illnesses are due to the failure to make this diagnosis and apply more appropriate treatment.

Patients with PDD/ASD cause considerable diagnostic difficulties in both inpatient and outpatient adolescent and adult psychiatry. Clinical experience suggests that patients with PDD/ASD in adulthood have been misdiagnosed as having schizophrenia resulting in inappropriate treatment. Mesibov and Handlan state that the diagnostic situation is complicated because the characteristics of autism are less pronounced in older clients. It is critical that an accurate diagnosis is given because of the specific treatment implications. In the past decade there have been considerable developments in our understanding of autism. The importance of bringing the developmental viewpoint into adult psychiatry is now highly relevant. Unfamiliar diagnostic categories now have to be considered by adolescent and adult psychiatrists. Grounds for the deletion of adult psychiatric disorders, eg. simple schizophrenia from ICD102 may exist. Instead PDD/ASD disorder may need to be considered.

As the purpose of diagnosis is to ensure appropriate client management, it is essential that diagnostic criteria are continually reviewed in view of clinical observation and research developments. In this paper, diagnostic categories causing confusion are outlined, and that these are variants of the core deficit of autism is suggested. The major PDD/ASD diagnoses in adolescence and adulthood are listed below.

Two of the following are required for the diagnosis of autism:

Type
Perspective
Copyright
Copyright © Cambridge University Press 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Mesibov, GB, Handlan, S. Adolescent and adults with autism. In: Cohen, DJ, Volkmar, FR (eds). Handbook of autism and pervasive developmental disorder. New York: Wiley, 1997.Google Scholar
2.World Health Organisation. International Classification of Diseases (10th edition) Clinical description and diagnostic guidelines. Geneva: WHO, 1992.Google Scholar
3.American Psychiatric Association. Diagnostic and Statistical Manual – IV. Washington DC: American Psychiatric Association, 1994.Google Scholar
4.Asperger, H. Die “Autistiscnen Psychopathen” im Kindesaiter. Archives fur Psychiatrie und Nervenkrankheiten 1944; 117: 76136.CrossRefGoogle Scholar
5.Ehlers, S, Gillberg, C. The epidemiology of Asberger's syndrome. A total population study. J Child Psych Child Psychiat 1993; 34: 1327–50.CrossRefGoogle ScholarPubMed
6.Chaziuddin, M, Butler, E, Tsai, LY, Ghaziuddin, N. Is clumsiness a marker for Asperger's syndrome? J Intell Disabilities Research 1994; 38(5): 519–27.CrossRefGoogle Scholar
7.Gillberg, C. Asperger's syndrome in 23 Swedish children. Developmental Med Child Neur 1989; 31: 520–31.CrossRefGoogle ScholarPubMed
8.Tantam, D. Asperger's syndrome in adulthood. In: Frith, U (ed). Autism and Asperger's syndrome. Cambridge: Cambridge University Press, 1991.Google Scholar
9.Tsai, LY. Diagnostic issues in high functioning autism. In: Schopler, F, Mesibov, G (eds). High functioning individuals with autism. NY: Plenum Press, 1992.Google Scholar
10.Wolff, S, Chick, J. Schizoid personality in childhood: a controlled follow up study. Psych Med 1980; 10: 85100.CrossRefGoogle ScholarPubMed
11.Van, Krevelen DA. Early infantile autism an autistic psychopathy. J Autism Childhood Schizophrenia 1971; 1: 82–6.Google Scholar
12.Tantam, DJH. Life long eccentricity and social isolation: II. Asperger's syndrome or schizoid personality disorder? Br J Psychiatry 1988; 153: 783–91.CrossRefGoogle ScholarPubMed
13.Myklebust, HR. Non-verbal learning disabilities: assessment and intervention. In: Myklebust, HR (ed). Progress in learning disabilities. New York: Grune and Stratton, 1975.Google Scholar
14.Rourke, BP, Young, GC, Leenaar, SAA. A childhood learning disability that predisposes those afflicted to adolescent and adult depression and suicide risk. J Learning Disabilities 1989; 22: 169175.CrossRefGoogle ScholarPubMed
15.Klin, Aet al.Validity and neuropsychological characterisation of Asperger's syndrome: convergence with non-verbal learning disabilities syndrome. J Child Psych Psychiat 1995; 36(7): 1127–40.CrossRefGoogle Scholar
16.Denckla, MB. The neuropsychology of social-emotional learning disabilities. Arch Neur 1983; 40: 461–2.CrossRefGoogle ScholarPubMed
17.Weintraub, S, Mesulam, MM. Developmental learning disabilities of the right hemisphere: emotional, interpersonal, and cognitive components. Arch Neur 1983; 40: 463–8.CrossRefGoogle ScholarPubMed
18.Voeller, KKS. Right-hemisphere deficit syndrome in children. Am J Psychiat 1986; 143: 1004–9.Google ScholarPubMed
19.Rapin, I, Allen, D. Developmental language disorders: Nosological considerations. In: Kirk, U (ed). Neuropsychology of language, reading, and spelling. New York: Academic Press, 1983.Google Scholar
20.Attwood, T. Asperger's syndrome. London: Jessica Kingsley, 1988.Google Scholar
21.Kendler, KS, McGuire, M, Gruender, GA, Walsh, D. An epidemiologic, clinical and family study of simple schizophrenia in Co Roscommon, Ireland. Am J Psychiatry 1994; 151(1) 2734.Google Scholar
22.Ramsey, JM, Andresen, NC, Rapoport, JL. Thought, language, communication, and affective flattening in autistic adults. Arch Gen Psychiat 1986; 43: 741–77.Google Scholar
23.Wing, L. Asperger's syndrome: a clinical account. Psychol Med 1981; 11: 115–30.CrossRefGoogle ScholarPubMed
24.Bleuler, F. Dementia praecox or the group of schizophrenias. Translated by G, Zinkin. New York: International University Press, 1950.Google Scholar
25.Kahlbaum, K. “Ueber Hebiodophrenie”. Allegemeine Zeitschrift Psychiatrie Psychisch-Gerichtliche Medicin 1890; 46: 461–74.Google Scholar
26.Black, DW, Bofelli, TD. Simple schizophrenia: Past, present, and future. Am J Psychiatry 1989; 146: 1267–73.Google ScholarPubMed
27.Kraeplin, F. Dementia praecox and paraphrenia. In: Textbook of Psychiatry, 8th Edition. Edinburgh: ES Livingstone, 1919; 176–7.Google Scholar
28.White, WA. Outlines of Psychiatry, 7th Edition. Washington DC: Nervous and Mental Disease Publishing Company, 1919.Google Scholar
29.Sadler, WS. Theory and Practice of Psychiatry. St Louis, MS: CV Mosby, 1936.CrossRefGoogle Scholar
30.Lehmann, HF. Schizophrenia, Four As: clinical features. In: Freeman, AM, Kaplan, HL (eds). Comprehensive Textbook of Psychiatry, 1st Edition. Baltimore MD: Williams and Wilkins, 1967; 60–3.Google Scholar
31.World Health Organisation. ICD-9. Geneva: WHO, 1978.Google Scholar
32.Lewis, ND. Research in dementia praecox. Past attainments, present trends, and future possibilities. New York: Committee on Mental Hygiene, 1936.Google Scholar
33.World Health Organisation. An international follow-up study of schizophrenia. New York: Wiley, 1979.Google Scholar
34.Stone, AA, Hopkins, R, Mahnke, MW. Simple schizophrenia syndrome or shibboleth. Am J Psychiatry, 125: 305–12.CrossRefGoogle Scholar
35.Strauss, JS, Carpenter, WJ. Schizophrenia. New York: Plenum, 1981.CrossRefGoogle ScholarPubMed
36.American Psychiatric Association. DSM-III-R. Washington DC: APA, 1987.Google Scholar
37.McKenna, K, Gordon, C, Lenane, M, Kaysen, D, Fahey, K, Rapoport, J. Looking for childhood onset schizophrenia: the first 71 cases screened. J Am Acad Child Adol Psychiat 1994; 33: 636–44.CrossRefGoogle ScholarPubMed
38.Kumra, Set al.Multidimensionally impaired disorder: is it a variant of very early onset schizophrenia? J Am Acad Child Adol Psychiat 1998; 37(1): 91–9.CrossRefGoogle ScholarPubMed
39.Fitzgerald, M. Multidimensionally impaired disorder. J Am Acad Child Adol Psychiat 1998; 37(11): 1125.CrossRefGoogle ScholarPubMed
40.Cohen, D, Paul, R, Volkmar, F. Issues in classification of pervasive developmental disorders and associated conditions. In: Cohen, DJ, Donnellan, AM (eds). Handbook of Autism and Pervasive Developmental Disorders. New York: Wiley, 1997; 2039.Google Scholar
41.Kumra, S. Multidimensionally impaired disorder. J Am Acad Child Adol Psychiat 1998; 37(11): 1125–6.CrossRefGoogle ScholarPubMed
42.Towbin, K, Dykens, F, Pearson, G, Cohen, D. Conceptualising borderline Syndrome of childhood and childhood schizophrenia as a developmental disorder. J Am Acad Child Adol Psychiat 1993; 32: 775–82.CrossRefGoogle ScholarPubMed
43.Gillberg, C. Asperger's syndrome and high functioning autism. Br J Psychiat 1998; 172: 200–9.CrossRefGoogle ScholarPubMed
44.Van der, Gaag RJ, Buitelaar, J, Ban, EVD, Bezemer, M, Njio, L, Engeland, HV. A controlled multivariate chart review of multiple complex developmental disorder. J Am Acad Child Adol Psychiat 1995; 34: 10961106.CrossRefGoogle Scholar
45.Robins, E, Guze, S. Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. Am J Psychiat 1970; 126: 107111.CrossRefGoogle ScholarPubMed
46.Fitzgerald, M. Adult attention deficit hyperactivity disorder. Ir J Psych Med 1998; 15(3): 82–3.CrossRefGoogle Scholar
47.McDougal, CJet al.A case-controlled study of repetitive thoughts and behaviour in adults with autistic disorder and obsessive compulsive disorder. Am J Psychiatry 1995; 152(5): 772–7.Google Scholar
48.Baron-Cohen, S. Do autistic children have obsessions and compulsions'? Br J Clin Psych 1989; 28: 193200.CrossRefGoogle ScholarPubMed
49.Nagy, J, Szatmari, P. A chart review of schizotypal personality disorders. J Autism Dev Dis 1986; 16(3): 351–67.CrossRefGoogle ScholarPubMed
50.Ryan, RM. Treatment resistant chronic mental illness: Is it Asperger's syndrome? Hospital and Community Psychiatry 1992; 43(8): 807–11.Google ScholarPubMed
51.Kumra, et al, unpublished, 1998.Google Scholar