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Single Photon Emission Computed Tomography Using 99mTc-HM-PAO in the Routine Evaluation of Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

T.A. Hurwitz ,
W. Ammann ,
D. Chu ,
C. Clark ,
J. Holden  and
R. Brownstone
T.A. Hurwitz*
Affiliation:
Department of Psychiatry, University of British Columbia
W. Ammann
Affiliation:
Department of Nuclear Medicine, University of British Columbia
D. Chu
Affiliation:
Department of Nuclear Medicine, University of British Columbia
C. Clark
Affiliation:
Department of Psychiatry, University of British Columbia
J. Holden
Affiliation:
Department of Pathology, University of British Columbia
R. Brownstone
Affiliation:
Department of Physiology, University of Manitoba
*
Department of Psychiatry, University Hospital, UBC Site, 2255 Wesbrook Mall, Vancouver, B.C., Canada V6T 2A1
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Abstract:

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Regional cerebral blood flow was studied in 7 patients with clinically suspected Alzheimer's disease and 10 normal controls by single photon computed emission tomography (SPECT) using HM-PAO. All patients with Alzheimer's disease and no controls had parietal lobe hypoperfusion which was usually bilateral. In patients with more severe dementia hypoperfusion extended into the frontal lobes. Parietal lobe hypoperfusion corresponds to parietal lobe degeneration which is the one of the first neocortical regions to show the typical degenerative changes of Alzheimer's disease. SPECT with HM-PAO is a non-invasive investigation available in most nuclear medicine departments and complements existing tests in the routine evaluation of patients presenting with dementia.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 1 , February 1991 , pp. 59 - 62
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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