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Mechanisms of Tumor-Associated Edema: A Review

Published online by Cambridge University Press:  18 September 2015

Rolando F. Del Maestro ,
Joseph F. Megyesi  and
Catherine L. Farrell
Rolando F. Del Maestro*
Affiliation:
Brain Research Laboratories, Experimental Research Unit, Department of Clinical Neurological Sciences, University of Western Ontario, London
Joseph F. Megyesi
Affiliation:
Brain Research Laboratories, Experimental Research Unit, Department of Clinical Neurological Sciences, University of Western Ontario, London
Catherine L. Farrell
Affiliation:
Brain Research Laboratories, Experimental Research Unit, Department of Clinical Neurological Sciences, University of Western Ontario, London
*
Brain Research Laboratories, Victoria Hospital, 375 South Street, London, Ontario, Canada N6A 4G5
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Abstract:

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An understanding of the mechanisms responsible for tumor-associated edema involves the elucidation of the role played by a number of intra-related processes. These include (i) the permeability of new tumor microvessels that are associated with tumor angiogenesis; (ii) alterations in microvascular permeability due to factors secreted by tumor cells; (iii) immunological mechanisms and (iv) increased microvessel permeability associated with inflammation. The rationale for a role for inflammatory processes in tumor-associated edema has been outlined and the role of non-steroidal anti-inflammatory drugs in modulating experimental and human tumor-associated edema has been explored.

Résumé:

RÉSUMÉ:

La compréhension des mécanismes responsables de l'oedème associé à des tumeurs implique Pélucidation du rôle de certains processus inter-reliés. Ce sont (I) la perméabilité des nouveaux microvaisseaux de la tumeur qui sont associés à l'angiogénèse tumorale; (II) les altérations de la perméabilité microvasculaire due à des facteurs sécrétés par les cellules tumorales; (III) des mécanismes immunologiques et (IV) une perméabilité accrue des microvaisseaux associée à l'inflammation. Nous justifions le rôle de processus inflammatoires dans l'oedème associé aux tumeurs et nous explorons le rôle des anti-inflammatoires non-stéroïdiens dans la modulation de l'oedème associé aux tumeurs, dans le contexte expérimental et humain.

Type
Neurosurgical Symposium - William S. Keith, Visiting Professorship in Neurosurgery
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 2 , May 1990 , pp. 177 - 183
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

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