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Long-term outcomes of acute treatment with cognitive therapy v. interpersonal psychotherapy for adult depression: follow-up of a randomized controlled trial

Published online by Cambridge University Press:  24 May 2018

Lotte H.J.M. Lemmens ,
Suzanne C. van Bronswijk ,
Frenk Peeters ,
Arnoud Arntz ,
Steven D. Hollon  and
Marcus J.H. Huibers
Lotte H.J.M. Lemmens*
Affiliation:
Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Suzanne C. van Bronswijk
Affiliation:
Department of Psychiatry and Psychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Frenk Peeters
Affiliation:
Department of Psychiatry and Psychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
Arnoud Arntz
Affiliation:
Department of Clinical Psychology, University of Amsterdam, PO Box 19268, 1000 GG Amsterdam, The Netherlands
Steven D. Hollon
Affiliation:
Department of Psychology, Vanderbilt University, 306 Wilson Hall, Nashville, Tennessee, USA
Marcus J.H. Huibers
Affiliation:
Department of Clinical Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA, 19104-6241, USA
*
Author for correspondence: Lotte Lemmens, E-mail: Lotte.Lemmens@Maastrichtuniversity.nl
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Abstract

Background

Although equally efficacious in the acute phase, it is not known how cognitive therapy (CT) and interpersonal psychotherapy (IPT) for major depressive disorder (MDD) compare in the long run. This study examined the long-term outcomes of CT v. IPT for MDD.

Methods

One hundred thirty-four adult (18–65) depressed outpatients who were treated with CT (n = 69) or IPT (n = 65) in a large open-label randomized controlled trial (parallel group design; computer-generated block randomization) were monitored across a 17-month follow-up phase. Mixed regression was used to determine the course of self-reported depressive symptom severity (Beck Depression Inventory II; BDI-II) after treatment termination, and to test whether CT and IPT differed throughout the follow-up phase. Analyses were conducted for the total sample (n = 134) and for the subsample of treatment responders (n = 85). Furthermore, for treatment responders, rates of relapse and sustained response were examined for self-reported (BDI-II) and clinician-rated (Longitudinal Interval Follow-up Evaluation; LIFE) depression using Cox regression.

Results

On average, the symptom reduction achieved during the 7-month treatment phase was maintained across follow-up (7–24 months) for CT and IPT, both in the total sample and in the responder sample. Two-thirds (67%) of the treatment responders did not relapse across the follow-up period on the BDI-II. Relapse rates assessed with the LIFE were somewhat lower. No differential effects between conditions were found.

Conclusions

Patients who responded to IPT were no more likely to relapse following treatment termination than patients who responded to CT. Given that CT appears to have a prophylactic effect following successful treatment, our findings suggest that IPT might have a prophylactic effect as well.

Keywords

Cognitive therapyinterpersonal psychotherapyoutcome studieslong-term outcomesmajor depressionrelapsesustained response.
Type
Original Articles
Information
Psychological Medicine , Volume 49 , Issue 3 , February 2019 , pp. 465 - 473
Copyright
Copyright © Cambridge University Press 2018 

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