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Over-expression of cyclo-oxygenase-2 predicts poor survival of patients with nasopharyngeal carcinoma: a meta-analysis

Published online by Cambridge University Press:  16 March 2020

C-C Sim  and
E U-H Sim
C-C Sim
Affiliation:
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia
E U-H Sim*
Affiliation:
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia
*
Author for correspondence: Prof Edmund Ui-Hang Sim, Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan94300, Malaysia E-mail: uhsim@unimas.my Fax: +60 825 831 60
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Abstract

Objectives

The conclusive prognostic significance of cyclo-oxygenase-2 has been determined in various cancers but not in nasopharyngeal carcinoma. Therefore, this study aimed to evaluate the relationship of cyclo-oxygenase-2 expression with the survival outcome and treatment response of nasopharyngeal carcinoma patients via a systematic meta-analysis approach.

Methods

A meta-analysis was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (‘PRISMA’) checklist. The primary clinical characteristics of patients, and hazard ratios with 95 per cent confidence intervals of overall survival data, were tabulated from eligible studies. The relationship of cyclo-oxygenase-2 expression with survival outcome (expressed as hazard ratio) and treatment response (expressed as odds ratio) in nasopharyngeal carcinoma patients was analysed, and explained with the aid of forest plot charts.

Results and conclusion

The pooled hazard ratio for overall survival was 2.02 (95 per cent confidence interval = 1.65–2.47). This indicates that the over-expression of cyclo-oxygenase-2 is significantly associated with the poor survival of nasopharyngeal carcinoma patients. The pooled odds ratio of 0.98 (95 per cent confidence interval = 0.27–3.49) reveals that over-expression of cyclo-oxygenase-2 was not significantly related to the treatment outcome.

Keywords

Cyclooxygenase-2Nasopharyngeal CarcinomaNasopharyngeal NeoplasmsPrognosisMeta-Analysis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 134 , Issue 4 , April 2020 , pp. 338 - 343
Copyright
Copyright © JLO (1984) Limited, 2020

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Footnotes

Prof E U-H Sim takes responsibility for the integrity of the content of the paper

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