Hostname: page-component-848d4c4894-5nwft Total loading time: 0 Render date: 2024-05-25T12:32:39.359Z Has data issue: false hasContentIssue false
  • English
  • Français

Genetic differences between substrains of the inbred mouse strain 101 and designation of a new strain 102

Published online by Cambridge University Press:  14 April 2009

John D. West ,
Mary F. Lyon ,
Josephine Peters  and
Paul B. Selby
John D. West
Affiliation:
MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 0RD, England
Mary F. Lyon
Affiliation:
MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 0RD, England
Josephine Peters
Affiliation:
MRC Radiobiology Unit, Chilton, Didcot, Oxon, OX11 0RD, England
Paul B. Selby
Affiliation:
Biology Division, Oak Ridge National Laboratory, PO Box Y, Oak Ridge, Tennessee 37830, U.S.A.

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Genetic polymorphisms revealed two distinct substrains of the inbred strain 101. One group included substrains 101*/Rl, 101/H and 101/HOxe; the other group comprised 101/El and 101/Sl. The two groups differed at 5 of the 8 genetic loci tested. The accompanying paper (Evans, Burtenshaw & Adler, 1985) shows that the two groups also differ for several chromosome polymorphisms. We suggest that genetic contamination occurred during the derivation of 101/El from 101/Rl and was already present in 101/El when 101/Sl was produced from this substrain. We further propose that these substrains be renamed 102/El and 102/Sl respectively.

Type
Short Papers
Information
Genetics Research , Volume 46 , Issue 3 , December 1985 , pp. 349 - 352
Copyright
Copyright © Cambridge University Press 1985

References

REFERENCES

Evans, E. P., Burtenshaw, M. D. & Adler, I. D. (1985). Chromosome differences between substrains of the inbred 101 mouse strain. Genetical Research 46, 353–356.CrossRefGoogle ScholarPubMed
Favor, J. (1983). A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutation Research 110, 367–382.CrossRefGoogle ScholarPubMed
Kratochvilova, J. (1981). Dominant cataract mutations detected in offspring of gamma-irradiated male mice. Journal of Heredity 72, 302–307.CrossRefGoogle ScholarPubMed
West, J. D. & Fisher, G. (1985). Inherited cataracts in inbred mice. Genetical Research 46, 45–56.CrossRefGoogle ScholarPubMed
West, J. D., Peters, J. & Lyon, M. F. (1984). Genetic differences between two substrains of the inbred 101 mouse strain. Genetical Research 44, 343–346.CrossRefGoogle ScholarPubMed