Original articleClarification of the esophageal function defect in patients with manometric ineffective esophageal motility: studies using combined impedance-manometry
Section snippets
Materials and methods
Since Food and Drug Administration approval of the technique of MII-EM in July 2002, all patients referred to our laboratory have undergone esophageal function testing using this technique. Approval for publishing information from esophageal function testing using combined MII-EM was obtained from the Institutional Review Board of the Medical University of South Carolina (Charleston, SC). All patients included in this study provided informed consent giving the investigators permission to use
Results
Seventy patients (35 women, 35 men; mean age, 54 yr; range, 17–86 yr) with a manometric diagnosis of IEM were identified from a total of 350 MII-EM studies between July 1, 2002, and March 31, 2003. Esophageal function testing was performed as either a primary diagnostic procedure or before ambulatory pH monitoring. The major symptom for which patients were referred was heartburn (41.4%), dysphagia (28.5%), chronic cough (10%), chest pain (7.1%), hoarseness (5.7%), regurgitation (5.7%), and
Discussion
We report on direct measurement of both esophageal pressures and bolus movement by using combined MII-EM technology in 70 patients with a manometric pattern consistent with the diagnosis of IEM. Interestingly, results are almost identical to those observed in a recent multicenter study of 43 healthy volunteers in which manometric ineffective contractions (<30 mm Hg) were shown to have complete bolus transit of liquid and viscous material in 48% and 34% of swallows, respectively.8 In the 70
References (15)
- et al.
Effect of peristaltic dysfunction on esophageal volume clearance
Gastroenterology
(1988) - et al.
Esophageal function testing using combined multichannel intraluminal impedance and manometry. Multicenter study of healthy volunteers
Clin Gastroenterol Hepatol
(2003) - et al.
Esophageal motility in reflux disease before and after fundoplicationa prospective, randomized, clinical, and manometric study
Gastroenterology
(2001) - et al.
Classification of oesophageal motility abnormalities
Gut
(2001) - et al.
Esophageal manometry in 95 healthy adult volunteers
Dig Dis Sci
(1987) - et al.
Esophagus
Intraluminal multiple electric impedance procedure for measurement of gastrointestinal motility
J Gastrointest Motil
(1991)
Cited by (166)
Obesity and esophageal dysmotility
2022, Obesity and Esophageal DisordersDevices for esophageal function testing
2022, VideoGIEDysphagia: Novel and Emerging Diagnostic Modalities
2021, Gastroenterology Clinics of North AmericaPresence of esophageal contractility after achalasia treatment is associated with improved esophageal emptying
2024, Neurogastroenterology and Motility