MR imaging of lymph nodes in patients with primary abdominal and pelvic malignancies using ultrasmall superparamagnetic iron oxide (Combidex)
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2012, Advances in Medical SciencesCitation Excerpt :The MRI has great potential for assessing the morphology of the lymphatic system. MR lymphangiography involves interstitial or intravenous injection of contrast agents, including dendrimers, liposomes, paramagnetic or ultrasmall superparamagnetic nanoparticles (~30 nm hydrodynamic radius) [112–115]. USPIO particles can migrate directly across blood capillaries into the medullary sinuses within the lymph node or can be extravasated from vasculature to the interstitial space where they are transported to the lymph nodes via the lymphatic vessels [116].
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2006, Surgical Clinics of North AmericaCitation Excerpt :Accurate assessment of nodal status should also take in account the morphology of the perinodal tissue. Clinical research on lymph node imaging agents such as ultrasmall iron–oxide particles, as described in the rectal staging portion of this article, may improve accuracy of staging nodal involvement [74,75]. In summary, MRC may become an important tool in the screening for, and assessment of, known colorectal cancer.
Lymphotropic nanoparticle enhanced MR imaging (LNMRI) technique for lymph node imaging
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