Abstract
The serotonin transporter (HTT) is a candidate gene for obsessive-compulsive disorder (OCD) that has been associated with anxiety-related traits. The long (l) and short (s) variants of the HTT promoter have different transcriptional efficiencies. HTT promoter genotype and blood 5-HT concentration were examined in 70 subjects from 20 families ascertained through children and adolescents with a DSM-III-R diagnosis of OCD. The HTT promoter variant had a significant effect on blood 5-HT content. Subjects with the l/l and l/s genotypes had significantly higher blood 5-HT levels than did those with the s/s genotype. There was a significant interaction between HTT promoter genotype and seasonal variation in blood 5-HT content, with significant seasonal differences in 5-HT occurring only in the subjects with thel/l genotype. Further studies of the regulation of HTT gene expression are indicated. © 1998 American College of Neuropsychopharmacology
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Hanna, G., Himle, J., Curtis, G. et al. Serotonin Transporter and Seasonal Variation in Blood Serotonin in Families with Obsessive-Compulsive Disorder. Neuropsychopharmacol 18, 102–111 (1998). https://doi.org/10.1016/S0893-133X(97)00097-3
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DOI: https://doi.org/10.1016/S0893-133X(97)00097-3
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