Journal of the American Academy of Dermatology
Is cutaneous plasmacytosis a distinct clinical entity?☆,☆☆
Section snippets
CASE REPORT
A 27-year-old Japanese man had an asymptomatic eruption on the trunk for 3 years. He had six red-brown plaques up to 3 cm in diameter. During the next 5 years the number of plaques gradually increased, reaching a total of about 30 (Fig. 1) . However, the patient's general condition remained good. There was no lymphadenopathy and no anemia, fever, malaise, or dyspnea. The diagnosis was cutaneous plasmacytosis. Laboratory examination
REVIEW OF THE LITERATURE
Approximately 60 Japanese and two non-Japanese cases of skin lesions considered to be cutaneous plasmacytosis have been published in various forms, including abstracts. Of these, 30 cases were described in detail. The following four case reports were excluded from our review, although the title indicated the presence of cutaneous or systemic plasmacytosis: one case of plasma cell lymphocytoma, 6 one case of cutaneous plasmacytoma, 7 and two cases of systemic plasmacytosis without cutaneous
DISCUSSION
Our review of cutaneous plasmacytosis supports the concept of this disorder as a unique clinical entity. Extramedullary plasmacytoma and the other lymphoproliferative diseases in which plasma cells and lymphocytes are atypical and monoclonal have been ruled out. Plasmacytosis also should be differentiated from other diseases, including chronic infections, and collagen diseases that can be associated with a similar proliferation of plasma cells in the dermis.
It is debatable whether the diagnosis
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Cited by (33)
Cutaneous plasmacytosis: Report of 6 cases with or without systemic involvement
2013, Journal of the American Academy of DermatologyCitation Excerpt :In most cases the clinical presentation is very characteristic, with multiple reddish-brown infiltrated macules, plaques, and flat tumors located mainly on the trunk. The disease is sometimes accompanied by anemia, fever, and hypergammaglobulinemia.2 The most common manifestation of extracutaneous involvement is lymphadenopathy,6 as observed in our 3 patients with nodal disease.
Peculiar brownish eruption and superficial lymphadenopathy in a middle-aged man
2011, Dermatologica SinicaCutaneous infiltrates - non-lymphoid
2009, Weedon's Skin Pathology: Third EditionHigh ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis-is this a cutaneous manifestation of IgG4-related disease?
2009, Human PathologyCitation Excerpt :Most cases have followed a chronic and benign clinical course over a decade without spontaneous remission, suggesting that the condition is a benign reactive proliferation of plasma cells [1,9]. A few cases have followed an aggressive clinical course as lymphoma [15], lymphoid interstitial pneumonia [10], or renal failure [8,9]. Treatment has included topical and systemic corticosteroids [16], cyclophosphamide [4], topical tacrolimus [17], psoralen–UV-a, and other chemotherapy [6,9,18-20].
Treatment of facial lesion of cutaneous plasmacytosis with tacrolimus ointment [6]
2003, Journal of the American Academy of DermatologyProgressive Hyperpigmented Plaques: Answer
2019, American Journal of Dermatopathology
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Reprint requests: Satoko Shimizu, MD, Ogikubo Hospital, 3-1-24 Imagawa, Suginami, Tokyo, 167, Japan.
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