Case ReportHepatitis C viraemia after apparent spontaneous clearance in a vertically infected child
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Cited by (16)
Pediatric Hepatitis C
2020, Advances in PediatricsCitation Excerpt :Spontaneous resolution can occur up to 7 or 8 years of age, but is rare after 3 years of age [12–14]. Anywhere from 6% to 12% of children with chronic HCV infection will clear the virus [15], with the remainder of these children developing chronic infection [16]. Infected children have a low risk of progression of disease and only about 5% develop significant liver disease in childhood.
Hepatitis C virus infection in children and adolescents
2019, The Lancet Gastroenterology and HepatologyCitation Excerpt :After vertical acquisition of HCV, between 25% and 40% of infected children spontaneously clear the infection in the first 4 years of life,6,7,34 which is slightly higher than the rate that is reported in adults. A further 6–12% of children with chronic HCV infection are expected to clear the virus before adulthood,39,46,47 whereas the remainder will develop chronic infection that persists into adulthood. The spontaneous clearance rate of vertically acquired HCV infection is affected by host factors, such as the IL28B gene (the rs12979860 single nucleotide polymorphism located on chromosome 19),48,49 and natural killer cell cytolytic function,50 as well as by viral characteristics, such as HCV genotype.34
Hepatitis C viraemia after apparent spontaneous clearance
2016, The LancetRetrospective analysis of vertical Hepatitis C exposure and infection in children in Western New York
2023, BMC GastroenterologySpontaneous Clearance of Vertically Acquired Hepatitis C Infection: Implications for Testing and Treatment
2023, Clinical Infectious DiseasesEpidemiology and Natural History of Childhood-Acquired Chronic Hepatitis C: A Single-Center Long-Term Prospective Study
2022, Journal of Pediatric Gastroenterology and Nutrition