Autoregulation of Angiogenesis by Cells of the Vessel Wall

doi:10.1016/S0074-7696(08)60148-5

International Review of Cytology

Volume 185, 1998, Pages 1-43

https://doi.org/10.1016/S0074-7696(08)60148-5 Get rights and content

The cells of the vessel wall can regulate angiogenesis by producing growth factorsd, proteolytic enzymes, extracellular matrix components, cell adhesion molecules, and vasoactive factors. This property enables preexisting blood vessels to generate new vessels in the absence of exogenous angiogenic stimuli. Vascular autoregulation of angiogenesis can be studied by culturing rat aortic or venous explants in collagen gels under serum-free conditions. In this system, the combined effect of injury and exposure of explants to collagen triggers a self-limited angiogenic response. Interactions among endothelial cells, smooth muscle cells, and fibroblasts play a critical role in the regulation of this process. This chapter reviews the literature on angiogenesis, focusing on the vessel wall as a highly specialized and plastic tissue capable of regenerating itself through autocrine, paracrine, and juxtacrine mechanisms.

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Autoregulation of Angiogenesis by Cells of the Vessel Wall

Cell

Cell

J. Biol. Chem.

FEBS Lett.

Am. J. Ophtalmol.

Cell

J. Invest. Dermatol.

J. Surg. Res.

Cell

J. Biol. Chem.

J. Biol. Chem.

Cell Biol. Int. Rep.

J. Cranio-Maxillo-Facial Surg.

Cell Differ.

Exp. Mol. Pathol.

J. Biol. Chem.

Cell

Exp. Pathol.

J. Biol. Chem.

Biochim. Biophys. Acta

Formation of new capillary-like tubes in a three-dimensional in vitro model (aorta/collagen gel)

Anatomischer Anzeiger.

Isolation of a cationic polypeptide from human serum which stimulates the proliferation of 3T3 cells.

Proc. Natl. Acad. Sci. USA

Injury induces in vivo expression of PDGF and PDGF receptor mRNA in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.

Proc. Natl. Acad. Sci. USA

The sequence of events in the regression of corneal capillaries.

Lab. Invest.

In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.

Proc. Natl. Acad. Sci. USA

Vascular endothelium and diabetes mellitus.

The effects of platelet-derived growth factor in cultured microvessel endothelial cells.

J. Endocrinol.

Hypothesis: Vasa vasorum and neovascularization of human coronary arteries.

N. Engl. J. Med.

Vasoconstriction: A new activity for platelet-derived growth factor.

Science

Growth factor activity of endothelin on vascular smooth muscle.

Am. J. Physiol.

Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy.

Cancer Res.

Human brain pericytes differentially regulate expression of procoagulant enzyme complexes comprising the extrinsic pathway of blood coagulation.

Arterioscl. Thromb. Vasc. Biol.

Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.

Circulation

Requirement of vascular integrin αvβ3 for angiogenesis.

Science

A novel in vitro assay of human angiogenesis.

Lab. Invest.

Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.

J. Exp. Med.

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

J. Cell Biol.

Role of tissue factor in embryonic tissue development.

Nature

Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor and the plasminogen system.

Impaired arterial neointima formation in mice with disruption of the plasminogen gene.

J. Clin. Invest.

Vascular endothelial cells migrate centripetally within embryonic arteries.

Anat. Embryol.

Microscopic observation on the growth of blood capillaries in the living mammal.

Am. J. Anat.

Purification and characterization of biologically active scatter factor from ras-transformed NIH 3T3 conditioned medium.

Biochem. J.

In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease.

Nature Med.

Expression of basic fibroblast growth factor in normal human tissues.

Lab. Invest.

Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.

Am. J. Pathol.

Growth factor effects on cells of the vascular wall: A survey.

Growth Factors

Endothelial adherens junctions: Implications in the control of vascular permeability and angiogenesis.

J. Clin. Invest.

Intercellular junctions in the endothelium and control of vascular permeability.

Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells.

Hypertension

Requirement of vascular integrin α_vβ₃ for angiogenesis.