Esophageal manifestations of rheumatic disorders
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2017, Handbook of Systemic Autoimmune DiseasesCitation Excerpt :The study found slow acid clearance in the esophagus of SS patients with GER, suggesting a prolonged duration of reflux. This extended exposure of the esophagus to refluxed acid may result either from defective acid neutralization by salivary bicarbonates or from altered esophageal motility [21–24]. Ho et al. [25] described a high frequency of tertiary waves in patients with markedly abnormal pH that were significantly associated with the total reflux time, suggesting a relationship between these contractions and prolonged exposure of the esophageal mucosa to low pH values.
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