EFFECTS OF INCREASED INTRA-ABDOMINAL PRESSURE IN SEVERE OBESITY
Section snippets
Animal Studies
Several studies have evaluated the effects of acutely elevated IAP upon the cardiovascular, pulmonary, and central nervous systems in a porcine model, using either an infusion of isosmotic polyethylene glycol normally used for bowel cleansing (Go-Lytely®) or an intra-abdominal balloon. Polyethylene glycol was chosen because it is not osmotically active and is neither absorbed into the central circulation in significant amounts nor causes significant decreases in intravascular volume. UBPs
DISCUSSION
The relationship of central obesity to the constellation of health problems known collectively as “Syndrome X” appears well established.1 This has been presumed to be because of increased visceral fat metabolism. Increased UBP and its relationship to increased IAP has been used in postoperative patients as an indication for emergent re-exploration and abdominal decompression for an “acute abdominal compartment syndrome,” to correct oliguria and increased peak inspiratory pressures with
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Address reprint requests toHarvey J. Sugerman, MDBox 980519, MCV/VCURichmond, Virginia 23298–0519e-mail: [email protected]