A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats
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Abbreviations
pI
isoelectric point
mAb
monoclonal antibody
TAA
tumor-associated antigen
telution
elution time
IEX
ion exchange
CEC
cation exchange chromatography
AEC
anion exchange chromatography
SEC
size exclusion chromatography
RTCC
redirected T cell cytotoxicity
PQ
product quality
HCP
host cell protein
FcRn
neonatal Fc receptor
SPR
surface plasmon resonance
DSC
differential scanning calorimetry
DSF
differential scanning fluorimetry
LDH
lactate dehydrogenase
ALL
acute lymphoblastic leukemia
GMP
good manufacturing practice
CRO
contract research organization
Keywords
Bispecific antibody
Heterodimeric Fc
Fc engineering
Tumor-associated antigen × CD3
Developability
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These authors contributed equally to this work.
© 2018 The Authors. Published by Elsevier Inc.