Review
Embryonic stem cell strategies to explore neural crest development in human embryos

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Abstract

Controling embryonic stem cell fate in vitro has been a major challenge in the past decade. Several protocols have been developed to obtain neural crest derivatives in culture, using more or less defined conditions. Here, we present various strategies used to date to obtain neural crest specification and the markers that can be used to identify human neural crest cells.

Highlights

► Human neural crest (NC) cells are still poorly studied. ► Several NC markers used in model species have been validated in human. ► ES/IPS cells are a promising tool to understand human neural crest development. ► Various protocols have been developed to derive neural crest from stem cells.

Keywords

Neural crest
Human embryonic stem cells
In vitro culture

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Copyright © 2012 Published by Elsevier Inc.