Effect of Dexmedetomidine with Different Anesthetic Dosage on Neurocognitive Function in Elderly Patients After Operation Based on Neural Network Model

This paper uses a neural network model to study the protective effect of dexmedetomidine on the anesthesia recovery period and neurocognitive function in elderly patients undergoing radical resection of colorectal cancer. Eighty-eight patients with colorectal cancer who underwent radical surgery in our hospital from January 2015 to June 2017 were randomly divided into groups: study (43 cases) and control (45 cases). The study group was treated with dexmedetomidine for anesthesia. Patients in the study group were given a slow pumping dose of 1 μg/kg to prepare dexmedetomidine at a dose of 1 μg/kg. The pumping time was >10 minutes, and the dose was 0.3 μg after completion. The loading dose of 0.3 (kg·h) was maintained intraoperatively; the control group was given the same amount of saline infusion by the same infusion method. The study found that the probability of cognitive dysfunction in the study group was significantly lower than that in the control group, and the degree of cognitive dysfunction in the study group was significantly lower than that in the control group (P < 0.05). Therefore in the operation of elderly patients with colorectal cancer radical surgery, dexmedetomidine is used for anesthesia to protect postoperative cognitive function and reduce the incidence of cognitive dysfunction. Extensive promotion and application in the clinic.

Introduction

According to relevant information, >50% of people older than age 65 will undergo at least 1 operation in their lives.¹ The phenomenon of weakened physiologic function in the elderly population leads to a weaker tolerance to surgery and an increased probability of complications. Among the many complications, the occurrence of cognitive dysfunction after surgery has attracted the attention of relevant personnel. Postoperative cognitive dysfunction is a phenomenon in which no abnormalities are found in the preoperative examination, but the disorder of brain function after surgery is a common postoperative complication. Anxiety, memory impairment, amnesia, agitation, cognitive ability, and decline in language ability are the main symptoms, and there may even be confusion.

Recently, related studies have shown that inflammation and stress response have a considerable impact on the development of postoperative cognitive dysfunction. Trauma factors such as surgery and anesthesia can cause sterile inflammation in patients. Inflammatory factors can cross the blood-brain barrier through various pathways, resulting in inflammation of the nervous system, especially the hippocampus, and increased cell membrane permeability. The phenomenon of enema has an adverse effect on the synaptic connection function. On the other hand, inflammatory factors can stimulate microglia in the central nervous system. These microglia will further secrete inflammatory factors, aggravating the inhibition of hippocampal neurons and leading to cognitive dysfunction in patients.² Maintaining perioperative hemodynamic stability, reducing stress response caused by surgical trauma, reducing postoperative complications, and improving postoperative recovery are the focus of perioperative anesthesia. For colorectal cancer radical surgery in elderly patients, the choice of anesthetics and analgesia should be fully evaluated and comprehensively consider the effects of drugs and analgesic methods on postoperative cognitive function in the elderly, which can effectively avoid postoperative recognition. Knowing dysfunction and performing surgery in the best condition.

Dexmedetomidine is a novel drug of α₂ adrenergic receptor agonist, which can be used for sedative, hypnotic, analgesic, anxiolytic, and sympathetic activity in clinical practice. Related studies have shown that dexmedetomidine can improve postoperative cognitive function in patients undergoing laparoscopic radical surgery for elderly patients with colorectal cancer. We studied the protective effect of dexmedetomidine on patients with anesthesia recovery and neurocognitive function in the operation of elderly patients undergoing radical resection of colorectal cancer. From January 2015 to June 2017, Hong Chen was selected. Eighty-eight elderly patients with colorectal cancer who underwent radical surgery were included in the study.