Elsevier

Vascular Pharmacology

Volume 112, January 2019, Pages 91-101
Vascular Pharmacology

Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta

https://doi.org/10.1016/j.vph.2018.10.005Get rights and content
Under a Creative Commons license
open access

Abstract

Vascular endothelial growth factors regulate vascular and lymphatic growth. Dysregulation of VEGF signaling is connected to many pathological states, including hemangiomas, arteriovenous malformations and placental abnormalities. In heart, VEGF gene transfer induces myocardial angiogenesis. Besides vascular and lymphatic endothelial cells, VEGFs affect multiple other cell types. Understanding VEGF biology and its paracrine signaling properties will offer new targets for novel treatments of several diseases.

Keywords

Vascular endothelial growth factor
VEGF
VEGF receptor
Heart
Angiogenesis
Lymphangiogenesis
Vascular tumor
Hemangioma
Arteriovenous malformation
Placenta
Lymphatic vessel

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