A chimeric influenza hemagglutinin delivered by parainfluenza virus 5 vector induces broadly protective immunity against genetically divergent influenza a H1 viruses in swine
Abbreviations
HA
hemagglutinin
PIV5
parainfluenza virus 5
PIV5-113
parainfluenza virus 5 expressing the HA from DNA expressing the HA-113 antigen
RSV
respiratory syncytial virus
MERS-CoV
Middle East Respiratory Syndrome Coronavirus
NJ76
A/New Jersey/8/1976
IA06
A/Iowa/01/2006
OH07
A/Ohio/01/2007
ME08
A/Memphis/03/2008
TN09
A/Tennessee/1-560/09
GE81
A/swine/Germany/2/1981
IA92
A/swine/Iowa/40766/1992
BR07
A/Brisbane/59/2007
CA09
A/California/4/2009
MI15
A/Michigan/45/2015
13E100
A/swine/Iowa/13E100/2013
BALF
bronchoalveolar lavage fluid
HAI
hemagglutination inhibition
ELISA
enzyme-linked immunosorbent assay
RDE
receptor-destroying enzyme
COBRA
computationally optimized broadly reactive antigen
FBS-PBST
Phosphate-buffered saline containing 10 % fetal bovine serum and 0.05 % Tween-20
IACUC
Institutional Animal Care and Use Committee
i.n.
intranasal
TCID50
50 % infectious dose in tissue culture
LD50
50 % lethal dose in mice
MDBK
Madin-Darby bovine kidney
MDCK
Madin-Darby canine kidney
MOI
multiplicity of infection
BHK
baby hamster kidney
NP
nucleoprotein
PR8
A/Puerto Rico/8/34
SH
small hydrophobic
HN
hemagglutinin-neuraminidase
ANOVA
Analysis of variance
IIV
inactivated influenza virus
LAIV
live, attenuated influenza virus
Keywords
Influenza
Universal vaccine
Interspecies transmission
Pigs
Mice
Cited by (0)
- 1
Current affiliation: CyanVac LLC, Athens, GA, 30602, United States.
- 2
Current affiliation: Department of Pediatrics, University of Pittsburgh, United States.
- 3
Current affiliation: Yangzhou University, Yangzhou, China.
- 4
Current affiliation: College of Veterinary Medicine, Department of Pathobiology, University of Illinois at Urbana-Champaign, United States.
- 5
Authors contributed equally to the work.
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