Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral and Maxillofacial SurgeryPlatelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift
Section snippets
Patient selection
This study is a case of 9 sinus elevations performed between January 2001 and June 2003 with FDBA (Phoenix; TBF, France) with or without PRF (Table I). The study was conducted in accordance with the standards of the Declaration of Helsinki of 1983. The patients were informed about the aim and design of the study and written consent was obtained.
Patients with immunologic diseases, unstable diabetes mellitus, ongoing chemo- or radiotherapy, or a history of drug abuse were excluded. The inclusion
Results
Preliminary analyses highlight mineralized trabecular bone rich in osteocytes with important oteoïd borders in contact with dense cellular osteoblast fronts (Fig. 1). Nevertheless, trabecular bone areas are less massive, more spaced and surrounded by adipose tissue. These observations especially concern apical parts of the samples. This phenomenon is explainable by the difficulty of correctly packing the bone graft particles in the entire sinus cavity during surgery. Even if such areas are less
Discussion
The aim of this histologic study was to evaluate the potential of PRF in combination with freeze-dried bone allograft to enhance bone regeneration in sinus floor elevation. Histomorphometric analysis shows that bone structures between control group (FDBA alone) and test group (FDBA+PRF) seem to be similar. But the healing period of the 2 groups was not identical (8 months and 4 months, respectively). Therefore, use of PRF with FDBA to perform sinus floor augmentation seems to accelerate bone
Conclusions
In this study, the histologic similarities observed between these 2 groups (FDBA alone and FDBA+PRF) make it possible to consider sinus floor augmentation surgery with a shorter healing period before implant placement (4 months instead of 8 months). Furthermore, the quantity of bone material used to fill the sinus cavity can be safely reduced without injuring the final bone density. Finally, the PRF membranes appear to be able to treat sinus membrane perforation and permit the surgery to be
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This article is an English translation of: Choukroun J, Simonpieri A, Girard MO, Schoeffler C, Dohan S, Dohan D. Les concentrés plaquettaires. 4ème partie: Analyses histologiques. Implantodontie 2004;13:167-72. Published in the French journal Implantodontie, Elsevier SAS. All rights reserved.