Case reportLiverNeoadjuvant Therapy Protocol and Liver Transplantation in Combination With Pancreatoduodenectomy for the Treatment of Hilar Cholangiocarcinoma Occurring in a Case of Primary Sclerosing Cholangitis: Case Report With a More Than 8-Year Disease-Free Survival
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Case Report
A 55-year-old woman with PSC-related cirrhosis underwent Magnetic resonance imaging (MRI) as part of her routine follow-up, which revealed a 20-mm hilar mass with intrahepatic biliary dilation but no gross vascular invasion. CA 19-9 was 1499 KU/L and a needle biopsy confirmed a well-differentiated CC with necrotic areas. In December 2001, she was treated according to protocol with external beam radiation and neoadjuvant chemotherapy with intravenous 5-fluoracil (5-FU). In January 2002, she was
Discussion
CC accounts for 3% of all gastrointestinal cancers1 and it is more common in patients with PSC, whose risk of developing this cancer is 8%–12%.2 Bile duct bifurcation (Klatskin tumors)1 is involved in 60%–70% of cases of CC, which arise in a critical anatomic position, often making their operative resection a challenge. Reports in the literature show that liver resection achieves 5-year survival rates of 20%–43%,3, 6 but this approach is unfortunately only feasible in a minority of cases.
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Cited by (6)
Clinical Cases in Hepatology
2021, Clinical Cases in HepatologyMachine Perfusion of the Liver: Applications Beyond Transplantation
2020, TransplantationCholangiocarcinoma
2015, Disease Recurrence After Liver Transplantation: Natural History, Treatment and SurvivalLiver transplantation for hilar cholangiocarcinoma
2013, World Journal of Gastroenterology