Elsevier

Translational Oncology

Volume 11, Issue 6, December 2018, Pages 1350-1357
Translational Oncology

Autophagy: A New Mechanism of Prosurvival and Drug Resistance in Multiple Myeloma

https://doi.org/10.1016/j.tranon.2018.08.014Get rights and content
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Abstract

Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. In physiological condition, autophagy funnels cytoplasmic constituents to autophagolysosomes for degradation and is an alternative way for cell-death behavior. Here, we inspected autophagy as a prosurvival mechanism essential for drug resistance in multiple myeloma (MM). Accordingly, autophagy inhibitors used in association to conventional anti-MM drugs might enforce the effect against resistant MM plasma cells and render autophagy a new therapeutic target.

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