Elsevier

Thrombosis Research

Volume 125, Issue 1, January 2010, Pages 102-104
Thrombosis Research

Letter to the Editors-in-Chief
Lupus Anticoagulant (LAC) testing in patients with inflammatory status: Does C-reactive protein interfere with LAC test results?

https://doi.org/10.1016/j.thromres.2009.09.001Get rights and content

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    Many assays for detecting LA are sensitive to CRP; this interferes with the results and results in false positives [21]. CRP is an acute phase protein with known affinity for APA [24,25,26]. In our study, although CRP levels were higher in LA-positive patients (p < 0.001) this variable did not emerge as a prognostic factor of mortality in the multivariate model.

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