Penicolinates A–E from endophytic Penicillium sp. BCC16054

doi:10.1016/j.tetlet.2012.11.028

Tetrahedron Letters

Volume 54, Issue 8, 20 February 2013, Pages 744-748

https://doi.org/10.1016/j.tetlet.2012.11.028 Get rights and content

Abstract

Five new picolinic acid derivatives, penicolinates A–E (1–5), together with four known compounds including phenopyrrozin (6), p-hydroxyphenopyrrozin (7), gliotoxin (8), and bisdethiobis(methylthio)gliotoxin (9) were isolated from endophytic Penicillium sp. BCC16054. The chemical structures were established from spectroscopic data-1D and 2D NMR experiments, IR, UV, and HRESIMS. These compounds were evaluated for antimalarial and antitubercular activities and for their activity against Bacillus cereus and Candida albicans along with cytotoxicity against both cancerous and non-cancerous cells.

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Acknowledgment

We are grateful to the National Center for Genetic Engineering and Biotechnology (BIOTEC) for financial support.

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Penicolinates A–E from endophytic Penicillium sp. BCC16054

Abstract

Graphical abstract

Section snippets

Acknowledgment

Phytochemistry

Phytochemistry

Methods

Tetrahedron Lett.

Science

J. Nat. Prod.

World J. Microbiol. Biotechnol.

Chem. Pharm. Bull.