NeoplasmLeptomeningeal carcinomatosis in a patient with metastatic prostate cancer: case report and literature review
Section snippets
Case report
A 76-year-old retired white male engineer was hospitalized in November 2004 for the recent onset of confusion and right-sided headaches in the frontoparietal and vertex area. These complaints had evolved over the past 5 days.
Of significance in his history was hypertension treated with diltiazem for 20 years and a diagnosis of prostate cancer treated by radical prostatectomy in October 1994. His PSA at the time of surgery was 12 ng/mL. A preoperative biopsy revealed an invasive poorly
Discussion
Leptomeningeal metastasis is found at autopsy in 5% of patients with systemic cancers [25]. However, an antemortem diagnosis is much less commonly confirmed, reflecting the difficulty in making the diagnosis clinically or with laboratory studies. Although it can be diagnosed when malignant cells are detected by cytological examination of the CSF, repeated examinations may be necessary to establish the diagnosis [21], [26], and even then, the CSF cytology is unremarkable in 5% to 10% of patients
References (26)
- et al.
Metastatic patterns of prostate cancer: an autopsy study of 1,589 patients
Hum Pathol
(2000) - et al.
The role of the vertebral veins in the dissemination of prostatic carcinoma
J Urol
(1981) - et al.
Brain metastases: an unusual complication from prostate cancer
Mayo Clin Proc
(2000) - et al.
Parenchymal brain metastases from adenocarcinoma of the prostate
Urology
(1986) - et al.
Meningeal carcinomatosis secondary to prostatic carcinoma; case report
J Urol
(1980) - et al.
Novel brain stem syndrome associated with prostate carcinoma
Neurology
(1993) The function of the vertebral veins and their role in the spread of metastases
Ann Surg
(1940)- et al.
Adenocarcinoma of prostate presenting as brain metastases
Cancer
(1984) Neurologic complications of prostate cancer
Am Fam Phys
(2002)- et al.
Malignancy and sensory neuropathy of unexplained cause: a prospective study of 51 patients
Arch Neurol
(1998)
Leptomeningeal metastasis: a comparison of gadolinium-enhanced MR and contrast-enhanced CT of the brain
Neurology
Intracranial metastases due to prostatic cancer
Cancer
Metastasis of prostatic adenocarcinoma simulating a falx meningioma
Surg Neurol
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Nonimaging evaluation of patients with nervous system metastases
2022, Neurological Complications of Systemic Cancer and Antineoplastic TherapyIntracranial meningeal carcinomatosis in metastatic castration resistant prostate cancer: Will extension of survival increase the incidence?
2012, Clinical Genitourinary CancerCitation Excerpt :Prostate cancer is known to commonly metastasize to the bone, while measurable soft tissue and visceral metastasis to the liver, lungs, and other sites are seldom seen in the advanced castration-resistant state. Intracranial meningeal carcinomatosis or dural metastases from prostatic adenocarcinoma are extremely rare and have been described in less than 30 cases in the literature.1,2 However, subclinical intracranial metastases may be more common.
Neurological complications of solid tumors
2012, Handbook of Clinical NeurologyCitation Excerpt :However, the leptomeninges are a common intracranial location to be involved in metastatic prostate cancer, followed by the cerebrum and cerebellum (Olson et al., 1974). Of the reported cases of LMM in metastatic prostate cancer, 4 patients developed LMM less than 1 year after being diagnosed, and 1 patient presented 10 years after diagnosis (Cone et al., 2006). Transitional cell carcinoma (TCC) of the bladder is the most common neoplasm of the urinary tract.
Dural metastases from prostate carcinoma: A systematic review of the literature apropos of six patients
2011, European Journal of RadiologyProstate cancer metastatic to the external auditory canals
2007, Clinical Genitourinary CancerA case report of prostate cancer with leptomeningeal metastasis
2022, Cancer Reports
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