Society of University SurgeonHyperglycemia modulates plasminogen activator inhibitor-1 expression and aortic diameter in experimental aortic aneurysm disease
Section snippets
Experimental models
All animal work was reviewed and approved by the Administrative Panel on Laboratory Animal Care committee at Stanford University. Inhaled isofluorane anesthesia was used for all operative procedures. Hyperglycemia was induced in male C57/BL6 mice (20 to 30g, 10 weeks of age; Jackson Laboratory, Bar Harbor, ME) via consecutive intraperitoneal injection of streptozotocin (STZ: 50 mg/kg; Sigma Aldrich, St. Louis, MO) dissolved in citrate buffer for 5 days as specified by the Animal Models of
AAA diameter is reduced in hyperglycemic mice
Immediately prior to elastase infusion, 3 weeks after initiation of STZ or buffer injections, blood glucose levels in the DM-AAA mice averaged 421 ± 14 mg/dL vs 147 ± 6 mg/dL in AAA mice, P < .05. There was no difference in mean aortic diameter between groups at baseline; DM-AAA mice had significantly decreased aortic diameters at postoperative day (POD) 7 (n = 4) and POD14 (n = 4) compared to AAA mice (also n = 4 at each time point; POD7: DM-AAA 0.92 ± 0.02 mm vs AAA 1.08 ± 0.05 mm, P < .05;
Discussion
Epidemiologic risk factors for AAA disease include advanced age, male gender, cigarette smoking, family history, hypertension, obesity, hypercholesterolemia, and concomitant atherosclerotic disease.7, 8 Although diabetes is a recognized risk factor for most acquired cardiovascular pathologies, recent observations consistently identify a negative association with AAA disease in both men and women.7, 8, 9, 10 The purpose of this study was to examine the influence of serum glucose levels on the
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2020, Journal of Vascular SurgeryCitation Excerpt :Interestingly, diabetes has been found to have an inverse relationship with abdominal aortic aneurysm incidence in multiple large population studies.11 However, the mechanisms by which hyperglycemia slows the aortic aneurysmal degeneration remain unclear.12,13 On the contrary, perioperative morbidity and mortality after abdominal aortic aneurysm repair are higher in diabetics largely because of the higher cardiovascular and infection risk.
Supported by the National Institutes of Health (2 R01 HL064338-08).