Original article
Genetic association of IL2RA, IL17RA, IL23R, and IL31RA single nucleotide polymorphisms with alopecia areata

https://doi.org/10.1016/j.sjbs.2022.103460Get rights and content
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Abstract

The signalling of cytokine receptors plays a crucial role in regulating tolerance and immunity. Impaired immunological processes result in autoimmune inflammation that target the hair follicles, causing many hair disorders, mainly alopecia areata (AA). Therefore, polymorphisms in cytokine receptor genes are suggested to have a significant impact on the pathogenesis of AA, a disease with a multifactorial basis and uncertain etiology. In the present study, 152 AA patients of the Jordanian population were investigated for their genetic susceptibility to develop AA compared to 150 control subjects. Genomic DNA extraction and genotyping had conducted for IL17RA (rs879575, rs2229151, and rs4819554), IL2RA (rs3118470), IL23R (rs10889677), and IL31RA (rs161704) using the Sequenom MassARRAY® system. The allele frequency of IL17RA rs879575 is significantly higher in patients, while no statistical differences were found for IL2RA, IL23R, and IL31RA SNPs. Also, the recessive model of IL31RA rs161704 showing that AA genotype is significantly associated with AA development. To date, there is no published data regarding the association between AA and the selected genetic variants in our population. However, this study's findings assert that SNPs of IL17RA and IL31RA are linked to AA susceptibility in Jordanian patients.

Keywords

Alopecia areata
Autoimmunity
Genetic predisposition
Hair disorders
Multifactorial disease

Abbreviations

AA
Alopecia Areata
IL2RA
Interleukin 2 receptor subunit alpha
IL17RA
Interleukin 17 receptor subunit alpha
IL23R
Interleukin 23 receptor
IL31RA
Interleukin 31 receptor subunit alpha
SNP
Single Nucleotide Polymorphism

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Peer review under responsibility of King Saud University.