Elsevier

Research in Veterinary Science

Volume 103, December 2015, Pages 51-53
Research in Veterinary Science

Evaluation of the in vitro activity of flumequine against field isolates of Brachyspira hyodysenteriae

https://doi.org/10.1016/j.rvsc.2015.08.013Get rights and content

Highlights

  • Representativeness and variability of the isolates used seem clear.

  • The use of quinolones in pig production in Europe is very low compared with other antibiotics.

  • Quinolones are not a routine antibiotics used against swine dysentery and their influence in the results is unlikely.

Abstract

Flumequine is a quinolone derivative used in veterinary medicine to treat enteric infections, mainly those caused by Gram negative bacteria and also some Gram positive. Some recent reports by field practitioners have suggested that its use in swine dysentery outbreaks can minimize the impact of this disease. This study aims to evaluate the in vitro anti-Brachyspira hyodysenteriae activity of flumequine. Forty eight field isolates of the bacterium were evaluated using a microdilution test. The lack of colon bioavailability studies of flumequine in pigs makes it difficult to establish the true efficacy of this antibiotic for swine dysentery control. Nonetheless, the relatively high values of MIC50 (50 μg/mL) and MBC50 (50 μg/mL) obtained suggest poor activity against B. hyodysenteriae. Flumequine activity in swine dysentery outbreaks could be related to its activity against other bacteria, different from B. hyodysenteriae, engaged in swine dysentery pathogenesis.

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Conflict of interest statement

None of the authors of this paper has a financial or personal relationship with other people or organizations that could inappropriately influence or bias the content of the paper.

Acknowledgments

The authors express their thanks to Gloria Fernández Bayón for her excellent technical assistance. This work was funded by the Spanish Ministry of Economy and Competitiveness (project AGL 2010-18804) and Laboratorios Syva S.A..

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