Case report
Focal lung infiltrate complicating PD-1 inhibitor use: A new pattern of drug-associated lung toxicity?

https://doi.org/10.1016/j.rmcr.2016.09.001Get rights and content
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Abstract

A 58-year-old woman with stage 4 adenocarcinoma of the lung being treated with pembrolizumab developed dyspnea, non-productive cough, and a right middle lobe infiltrate. Complete resolution of the infiltrate with cessation of pembrolizumab, initiation of prednisone and no antibiotic therapy suggested drug-associated lung toxicity as the cause. While the programmed death-1 (PD-1) inhibitors –pembrolizumab and nivolumab – have been implicated as a cause of diffuse or multifocal pulmonary infiltrates, the current case represents, to our knowledge, the first instance of a unilobar, focal infiltrate associated with their use. We speculate that the blockade of immune tolerance that is the hallmark of PD-1 inhibitors might cause atypical inflammatory reactions such as the focal lobar infiltrate seen in the current patient. Awareness of this novel radiographic pattern of drug-associated lung toxicity may enhance clinicians' management of patients receiving.

Keywords

PD-1 inhibitors
Pembrolizumab
Nivolumab
Drug toxicity
Lung cancer

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