Detection of neurodevelopmental diversity in memory clinics—Validation of a self-report measure
Section snippets
What this paper adds?
The influence of neurodevelopmental diversity on cognitive aging patterns re. Our research validates a self-report measure to reliably capture past childhood cognitive difficulties. This will facilitate further research on how early life neurodevelopment influences late life neurodegeneration.
Study population
Participants for this study were drawn from the community-based Weill Cornell Medical College Comparative Effectiveness Dementia & Alzheimer’s Registry (CEDAR) project. The CEDAR project is an observational clinical registry that was initiated in 2013 and uses an innovative platform that tracks in-office clinical care that includes an online educational model (www.AlzU.org) aimed at delivering the most up-to-date AD information to patients in real time.
A convenience sample of 369 subjects
Classification of subjects
Individuals were classified as having a childhood language, math or attention weakness if they scored abnormally (1.5 SD below mean) in only that respective domain. This 1.5 SD was chosen based on sensitivity analysis because the 1.0 SD was too inclusive and the 2.0 SD was too exclusive. Those scoring abnormally in multiple domains, a factor seen very common clinically, were classified as “Mixed”. Abnormal scores in sequential processing, working memory or executive function were classified as
Discussion
In this study, we hypothesized that self-report methods could reliably identify childhood cognitive difficulties in specific domains associated with NLAD (SLD reading, writing, math and ADHD) in people with memory disorders. This was important for helping to further understand the unique aspects of cognitive aging in this underrepresented population. A model including 15 items and fitting into six factors (Math, Language, Working Memory, Sequential Processing, Attention and Executive Function)
Conclusion
Self-reported childhood cognitive difficulty, detectable using a self-report scale, is surprisingly common in middle-aged and older adults with mild cognitive impairment. Further research is necessary to test whether retrospectively-reported childhood susceptibilities are in fact associated with neuropsychological, neuroimaging or neuropathological biomarkers of developmental learning or attention disorder. This could raise attention to neurodevelopmental diversity in the memory clinic, which
Conflicts of interests
The authors have no conflicts of interest to report related to this manuscript.
Acknowledgements
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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Suspected neurodevelopmental disorders in adult patients of memory clinics: Start at the beginning. GREDEV proposals for clinical practice
2023, Revue NeurologiqueCitation Excerpt :The questionnaires listed in Table 2 [16–34] are a selection of self-administered questionnaires, with priority given (where possible) to those that are adapted to adult populations, translated and validated in French, and useful as a screening tool (not too long, with an easy scoring process and interpretation). The Self-Reporting Questionnaire (SRQ) [16] was validated in 227 adults with memory complaints (41% male; mean age = 60) including 163 subjects without an NDD diagnosis and 64 patients with NDD (impairment in math = 12, language = 10, attention = 10, other or mixed = 32). Principle component analysis was performed but no cutoffs are given and no French version has been created or validated.
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