Review articleModulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
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Abbreviations
α-SYN
alpha synuclein
β-TrCP
β-transducin repeat containing E3 ubiquitin protein ligase
Aβ
amyloid beta
AD
Alzheimer's disease
ALS
amyotrophic lateral sclerosis
AMPK
AMP-activated protein kinase
ARE
antioxidant response element
ASK1
apoptosis-signal-regulating kinase 1
ATF-6
activating transcription factor 6
APP
amyloid precursor protein
CG islands
cytosine guanine islands
ChIP
chromatin immunoprecipitation
CJD
Creutzfeldt Jakob disease
CSF
cerebrospinal fluid
D3T
1,2-dithiole-3-thione
DMF
dimethyl fumarate
ER
endoplasmic reticulum
ERO1
sulfhydryl oxidase endoplasmic oxidoreductin 1
FOXO
forkhead box
GCLC
glutamate-cysteine ligase catalytic subunit
GCLM
glutamate-cysteine ligase modulatory subunit
GFP
green fluorescent protein
GLT-1
glutamate transporter 1
GPX
glutathione peroxidase
GR, GSR
glutathione reductase
GSH
glutathione (c-glutamyl-l-cysteinylglycine)
GSK-3
glycogen synthase kinase-3
GSSG
glutathione disulfide
GST
glutathione S-transferase
HD
Huntington's disease
Htt
huntingtin
HMOX1
heme oxygenase-1
IRE1
inositol-requiring kinase 1
JNK
c-Jun N-terminal kinase
KEAP1
kelch-like ECH-associated protein 1
MAPKs
mitogen-activated protein kinases
MPTP
1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
MEF
mouse embryonic fibroblasts
mTOR
mammalian target of rapamycin
NQO1
NAD(P)H:quinone oxidoreductase 1
NRF1
nuclear factor (erythroid-derived 2)-like 1
NRF2
nuclear factor (erythroid-derived 2)-like 2
LIR
LC3 interacting region
PERK
pancreatic ER eIF2α kinase
PD
Parkinson's disease
PDI
protein disulfide isomerase
PI3K
phosphatidyl inositol-3 kinase
PKA
protein kinase A
PKC
protein kinase C
PrP
prionic protein
PS1
presenilin 1
PRX
peroxiredoxin
ROS
reactive oxygen species
SFN
sulforaphane
SOD1
Cu/Zn-superoxide dismutase 1
TAK1
TGF-β-activated kinase 1
TFEB
transcription factor EB
UBA
ubiquitin associated domain
UPS
ubiquitin proteasome system
UPR
unfolded protein response
XBP1
X box-binding protein 1
γ-GCL
γ -glutamylcysteine synthetase
γGS
γ -glutamate cysteine synthetase
γGT
γ -glutamyl transpeptidase
Keywords
Neurodegenerative diseases
Unfolded protein response
Proteasome
Ubiquitin
Autophagy
Oxidative stress
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© 2017 The Authors. Published by Elsevier B.V.