Elsevier

Redox Biology

Volume 2, 2014, Pages 289-295
Redox Biology

Graphical Review
Oxidative stress and nerve damage: Role in chemotherapy induced peripheral neuropathy

https://doi.org/10.1016/j.redox.2014.01.006Get rights and content
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Highlights

  • Oxidative stress contributes to the pathophysiology of chemotherapy induced peripheral neuropathies (CIPN).

  • Mitotoxicity and mitochondrial dysfunction contribute to amplified oxidative stress.

  • Pharmacological interventions targeted at maintenance of mitochondrial health and function may be beneficial against CIPN.

Abstract

Peripheral neuropathy is a severe dose limiting toxicity associated with cancer chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) remain sparse and considerable involvement of oxidative stress and neuroinflammation has been realized recently. Despite the empirical use of antioxidants in the therapy of CIPN, the oxidative stress mediated neuronal damage in peripheral neuropathy is still debatable. The current review focuses on nerve damage due to oxidative stress and mitochondrial dysfunction as key pathogenic mechanisms involved in CIPN. Oxidative stress as a central mediator of apoptosis, neuroinflammation, metabolic disturbances and bioenergetic failure in neurons has been highlighted in this review along with a summary of research on dietary antioxidants and other nutraceuticals which have undergone prospective controlled clinical trials in patients undergoing chemotherapy.

Graphical abstract

Targeting chemotherpay induced peripheral neuropathy with natural antioxidants.

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Keywords

Chemotherapy
Mitochondria
Mitotoxicity
Nutraceuticals
Oxidative stress
Peripheral neuropathy

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