Systematic ReviewComparisons between radiofrequency ablation and stereotactic body radiotherapy for liver malignancies: Meta-analyses and a systematic review
Section snippets
Materials and method
We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic search was performed across databases including Medline and EMBASE. The search terms were designed to identify studies comparing treatment outcomes between RFA and SBRT for malignancies in the liver: (RFA OR radiofrequency) AND (SBRT OR stereotactic) AND (HCC OR hepatocellular OR liver). No language or publishing period restrictions were applied. In addition to published articles, we
Results
A total of 621 studies were initially obtained. After excluding reviews, letters, editorials, case reports and series, and laboratory studies, 208 studies were subjected to abstract review. In the abstract review, studies with irrelevant subjects were excluded and multiple published studies in a single institution were filtered according to the criteria described above. The remaining 27 studies were subjected to full-text review to exclude those with irrelevant subjects or that did not fully
Discussion
While comparisons of treatment modalities for HCC might seem to be a furious battle for some researchers [29], some clinicians find them more likely to be complementary [12]. Competition among modalities can cause disputes among clinicians but may also provide a driving force for the development of modalities. As there are overlapping and mutually complementary parts among competitive modalities, it is important to objectively understand the advantages and disadvantages of each modality to
Conflict of interest statement
All the authors have no conflicts of interests in terms of employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or any funding.
Acknowledgement
This work was supported by Inha University Hospital Research Grant.
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