Elsevier

Polymer

Volume 55, Issue 22, 23 October 2014, Pages 5511-5516
Polymer

Feature article
Modification of polypeptide materials by Thiol-X chemistry

https://doi.org/10.1016/j.polymer.2014.08.067Get rights and content

Abstract

Thiol-X chemistry has proven to be a valuable toolbox for modification of peptides, proteins, monomers, and polymers. Recently, this has become especially true for the modification of polypeptides (monomers or polymers), which has resulted in a plethora of novel polymers and materials. With this in mind, this highlight focuses on the recent literature concerning the modification of polypeptides by the use of thiol-X chemistry, in particular to synthetic polypeptides either at the monomer or polymer stage modified by thiol-ene, -Michael addition, and -yne chemistries.

Keywords

Polypeptide
Thiol-X
Click chemistry

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Sarah M. Brosnan received her B.S. in chemistry from the University of Massachusetts Amherst while conducting research in Prof. E. Bryan Coughlin's group. She then went on to receive her Ph.D. at the University of North Carolina at Chapel Hill under the supervision of Prof. Valerie Sheares Ashby in 2012, were she developed novel biomaterials for unique applications. Currently, she is an NSF post-doctoral fellow working at the Max Planck Institute for Colloids and Interfaces under the supervision of Prof. Markus Antonietti and Prof. Helmut Schlaad.

Helmut Schlaad studied chemistry at the University of Mainz, Germany, and earned a doctoral degree in Physical Chemistry, under Axel H. E. Müller in 1997. After a one year post-doctoral fellowship with Rudolf Faust at the University of Massachusetts in Lowell, USA, he moved to the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany. He finished habilitation, mentored by Markus Antonietti, and became senior scientist in 2004. He recently joined the University of Potsdam as Professor (W2) of Polymer Chemistry. His research interests are directed towards polymer synthesis, smart functional materials, and bioinspired structures based on synthetic and biohybrid polymers.

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