ReviewInnovative therapies for neuroblastoma: The surprisingly potent role of iron chelation in up-regulating metastasis and tumor suppressors and down-regulating the key oncogene, N-myc
Graphical Abstract
Section snippets
Prelude
Iron is an indispensable requirement for the activity of many essential metabolic processes as it plays critical roles in the active sites of many proteins involved in DNA synthesis, energy generation, etc. [1]. Neoplastic cells have a far more intense requirement for iron than normal cells, which is related to their rapid rate of proliferation [2]. As such, drugs that bind iron inhibit cancer cell proliferation, including the growth of aggressive tumors, for instance neuroblastoma [3].
Funding sources
D.R.R. thanks the National Health and Medical Research Council of Australia (NHMRC) for a Research Career Award (Senior Principal Research Fellowship; APP1159596).
Author contributions
T.P.W. and D.R.R. conceived and wrote the article with input from M.D. and C.C.D. All authors reviewed, revised and commented on the manuscript prior to submission.
Declaration of Competing Interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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