Relevance of the CXCR4/CXCR7-CXCL12 axis and its effect in pathophysiological conditions
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Graphical abstract
Abbreviations
AKT
protein kinase B
AR
androgen receptor
CNS
central nervous system
CRPC
castration-resistant prostate cancer
DLBL
diffuse large B-cell lymphoma
EAE
experimental autoimmune encephalomyelitis
EMT
endothelia mesenchymal transition
ER
estrogen receptor
ERK
extracellular signal-regulated kinase
GPCR
G protein coupled receptor
HIF-1α
hypoxia-inducible factor 1α
IL-8
interleukin 8
MAPK
mitogen-activated protein kinase
MS
multiple sclerosis
NSC
neural stem cell
OPC
oligodendrocyte progenitor cell
RA
rheumatoid arthritis
RCC
renal cell carcinoma
VEGF
vascular endothelial growth factor
Chemical compounds studied in this article
Balixafortide (PubChem CID: 138752609)
Decursin (PubChem CID: 442126)
Doxorubicin (PubChem CID: 31703)
Enzalutamide (PubChem CID: 15951529)
LY2510924 (PubChem CID: 129010506)
Mafosfamid (PubChem CID: 104746)
Motixafortide (PubChem CID: 91865076)
Olaptesed pegol (PubChem CID: 86278354)
Plerixafor (PubChem CID: 65015)
Ulocuplumab (PubChem SID: 381127169)
Keywords
Chemokine
Myocardial infarction
Renal cell carcinoma
Multiple sclerosis
Glioblastoma
Prostate carcinoma
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© 2020 The Author(s). Published by Elsevier Ltd.