Acrolein-mediated neurotoxicity in growing Wistar male rats
Graphical abstract
Section snippets
Introductıon
Acrolein, a highly electrophilic α,β-unsaturated aldehyde, is an environmental and food contaminant widely produced by thermal processed organic compounds including carbohydrates, amino acids and fats [1,2]. Human exposure to acrolein may occur via endogenously, diet or environmental sources such as oil-fried foods, tobacco smoke, incomplete combustion of plastic, wood and petrol [1,3]. Acrolein occurence was reported in foods, fruits and beverages such as raw cocoa beans, vegetable oils, white
Animals and experimental design
This study was set up to evaluate subchronic effects of orally administrated acrolein in terms of hematological, biochemical, histopathological and immunohistochemical analysis in growing Wistar male rats. 3–4 weeks aged Wistar male rats were provided from Production Center of Experimental Animals with the approval of Animal Experimentations Local Ethic Commitee of Hacettepe University. Rats were acclimatized for a week to our laboratory conditions, maintained in a temperature and humidity
Body weights, food and water consumption
According to results, acrolein treatment caused several changes in mean body weight gains. Body weight gains and percentage of body weight gains in 1 and 2 mg/kg/day acrolein treatment groups decreased statistically in response to acrolein exposure compared to control group (respectively, P = 0.0125; P = 0.0057). Food and water consumptions were not altered in all groups although water consumption increased in 0.5 mg/kg/day acrolein group, it was not statistically significant. Body weight gains
Discussion
In recent years, increase in central nervous system disorders is a major health problem. It is noteworthy that over 1 billion people worldwide have central nervous system disorders [21]. Among the central nervous system disorders, neurodegenerative diseases are the most engrossing resulting in identified by relatively age dependent decrease in neurological functions and accompanied by neuronal damage [21]. Although much of the neurodegenerative disorders are known to be age-related, recent
Acknowledgement
We thank to Hacettepe University Scientific Projects Coordination Unit (Project No: 010D08601008) for the financial support. This research is a MSc thesis of Gökçen Mülayimçelik Özgün.
References (41)
- et al.
Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo
Toxicol. Lett.
(2013) - et al.
Acrolein A2
- et al.
Mechanisms of CDDO-imidazolide-mediated cytoprotection against acrolein-induced neurocytotoxicity in SH-SY5Y cells and primary human astrocytes
Toxicol. Lett.
(2015) - et al.
Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures
Free Radic. Biol. Med.
(2000) - et al.
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Free Radic. Biol. Med.
(1991) - et al.
Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
Neurobiol. Aging
(2001) - et al.
Developmental neurotoxicity of succeeding generations of insecticides
Environ. Int.
(2017) - et al.
Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCε signaling and cardioprotection
J. Mol. Cell. Cardiol.
(2008) - et al.
Voxel-based cortical thickness measurements in MRI
NeuroImage
(2008) - et al.
Mild as well as severe insults produce necrotic, not apoptotic, cells: evidence from 60-min seizures
Neurosci. Lett.
(2010)
Nervous system, organization of A2
GFAP in health and disease
Prog. Neurobiol.
Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker
Trends Neurosci.
Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease
Mol. Nutr. Food Res.
Acute acrolein exposure induces impairment of vocal fold epithelial barrier function
PLoS ONE
Acrolein environmental levels and potential for human exposure
Toxicol. Ind. Health
Protein modification by acrolein: relevance to pathological conditions and inhibition by aldehyde sequestering agents
Mol. Nutr. Food Res.
Protein-bound Acrolein
J. Neurochem.
The molecular effects of acrolein
Toxicol. Sci.
Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death
Sci. Rep. UK
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