Elsevier

Surgical Pathology Clinics

Volume 11, Issue 4, December 2018, Pages 837-876
Surgical Pathology Clinics

Mesenchymal Neoplasms of the Genitourinary System: A Selected Review with Recent Advances in Clinical, Diagnostic, and Molecular Findings

https://doi.org/10.1016/j.path.2018.07.008Get rights and content

Section snippets

Overview

Mesenchymal neoplasms pose a unique challenge to surgical pathologists in general, a challenge facilitated by the sheer number of entities, the range of patterns of differentiation evident histologically, the histologic similarity of lesions with varying biologic potential, and the relative rarity of these tumors compared with epithelial neoplasms. Contemporary classifications of mesenchymal (specifically, soft tissue and bone) tumors use pathologic assessment of the pattern of differentiation

First page preview

First page preview
Click to open first page preview

References (263)

  • J. Weaver et al.

    Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma?

    Mod Pathol

    (2010)
  • S.F. Kammerer-Jacquet et al.

    Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry

    Hum Pathol

    (2017)
  • J. Weaver et al.

    Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms

    Mod Pathol

    (2008)
  • K. Dantey et al.

    Correlation of histological grade of dedifferentiation with clinical outcome in 55 patients with dedifferentiated liposarcomas

    Hum Pathol

    (2017)
  • L.C. Horn et al.

    Inflammatory pseudotumor of the ureter and the urinary bladder

    Pathol Res Pract

    (1997)
  • J.L. Hornick et al.

    Expression of ROS1 predicts ROS1 gene rearrangement in inflammatory myofibroblastic tumors

    Mod Pathol

    (2015)
  • M.R. Erickson-Johnson et al.

    Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion

    Lab Invest

    (2011)
  • A. Alkan et al.

    A paratesticular inflammatory myofibroblastic tumor and review of the literature

    J Oncol Sci

    (2017)
  • A.J. McCarthy et al.

    Tumours composed of fat are no longer a simple diagnosis: an overview of fatty tumours with a spindle cell component

    J Clin Pathol

    (2018)
  • F.M. Enzinger et al.

    Spindle cell lipoma

    Cancer

    (1975)
  • B.M. Shmookler et al.

    Pleomorphic lipoma: a benign tumor simulating liposarcoma. A clinicopathologic analysis of 48 cases

    Cancer

    (1981)
  • J.S. Ko et al.

    Spindle cell lipomas in women: a report of 53 cases

    Am J Surg Pathol

    (2017)
  • P. Dal Cin et al.

    Lesions of 13q may occur independently of deletion of 16q in spindle cell/pleomorphic lipomas

    Histopathology

    (1997)
  • C.D. Fletcher et al.

    Correlation between clinicopathological features and karyotype in lipomatous tumors. A report of 178 cases from the chromosomes and morphology (CHAMP) collaborative study group

    Am J Pathol

    (1996)
  • F. Maggiani et al.

    Extramammary myofibroblastoma is genetically related to spindle cell lipoma

    Virchows Arch

    (2006)
  • M.E. McMenamin et al.

    Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma

    Am J Surg Pathol

    (2001)
  • P. Pauwels et al.

    Myofibroblastoma of the breast: genetic link with spindle cell lipoma

    J Pathol

    (2000)
  • F. Maggiani et al.

    Cellular angiofibroma: another mesenchymal tumour with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)-mammary myofibroblastoma

    Histopathology

    (2007)
  • I. Panagopoulos et al.

    Loss of chromosome 13 material in cellular angiofibromas indicates pathogenetic similarity with spindle cell lipomas

    Diagn Pathol

    (2017)
  • B. Datta et al.

    Histopathological evaluation of surgically treated adult renal tumors: report from a tertiary care center in India

    Indian J Cancer

    (2016)
  • M. Sabah et al.

    Para-testicular cellular angiofibroma: a rare tumour in a male renal transplant patient

    Virchows Arch

    (2006)
  • B.E. Howitt et al.

    Mammary-type myofibroblastoma: clinicopathologic characterization in a series of 143 cases

    Am J Surg Pathol

    (2016)
  • Y. Iwasa et al.

    Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases

    Am J Surg Pathol

    (2004)
  • M.R. Nucci et al.

    Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma

    Am J Surg Pathol

    (1997)
  • C.D. Fletcher et al.

    Spindle cell lipoma: a clinicopathological study with some original observations

    Histopathology

    (1987)
  • G. Magro et al.

    CD10 is expressed by mammary myofibroblastoma and spindle cell lipoma of soft tissue: an additional evidence of their histogenetic linking

    Virchows Arch

    (2007)
  • M. Miettinen et al.

    Spindle cell/pleomorphic lipoma

  • M.P. Sachdeva et al.

    Low-fat and fat-free pleomorphic lipomas: a diagnostic challenge

    Am J Dermatopathol

    (2009)
  • S.D. Billings et al.

    Diagnostically challenging spindle cell lipomas: a report of 34 "low-fat" and "fat-free" variants

    Am J Dermatopathol

    (2007)
  • A. Beham et al.

    Spindle cell and pleomorphic lipoma: an immunohistochemical study and histogenetic analysis

    J Pathol

    (1989)
  • B.J. Chen et al.

    Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications

    Am J Surg Pathol

    (2012)
  • A. Marino-Enriquez et al.

    Atypical spindle cell lipomatous tumor: clinicopathologic characterization of 232 cases demonstrating a morphologic spectrum

    Am J Surg Pathol

    (2017)
  • H.L. Evans

    Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years

    Am J Surg Pathol

    (2007)
  • A.P. Dei Tos et al.

    Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases

    Am J Surg Pathol

    (1994)
  • A.T. Deyrup et al.

    Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas

    Am J Surg Pathol

    (2013)
  • D. Creytens et al.

    Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma

    Virchows Arch

    (2014)
  • S.W. Weiss et al.

    Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of "dedifferentiation"

    Am J Surg Pathol

    (1992)
  • E.P. Henske et al.

    Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas

    Genes Chromosomes Cancer

    (1995)
  • T. Takeda et al.

    A case of spindle cell lipoma in the inguinal region

    Hinyokika Kiyo

    (2016)
  • Disclosure Statement: Dr S.C. Smith discloses royalty/consulting income for textbook authorship with Amirsys/Elsevier Publishing.

    View full text