Original articleNatural History of Geographic Atrophy in Untreated Eyes with Nonexudative Age-Related Macular Degeneration: A Systematic Review and Meta-analysis
Section snippets
Methods
This meta-analysis is reported in accordance with the Meta-analysis of Observational Studies in Epidemiology checklist (Table S2, available at www.ophthalmologyretina.org).17
Database
The final search retrieved a total of 1649 records after de-duplication. After review of the titles and abstracts, 1595 records were excluded for irrelevance. We reviewed the full text of the remaining 54 articles and identified 25 independent studies (including 2942 unique eyes) meeting our inclusion criteria (Fig S1). The descriptive information of each study is detailed in Table S3, and excluded articles are listed in Table S4 (available at www.ophthalmologyretina.org).
Study Quality and Publication Bias
Newcastle-Ottawa scale
Discussion
To our knowledge, this is the first meta-analysis to evaluate the natural progression pattern of GA secondary to nonexudative AMD. Previous studies of the natural history of GA exhibited a wide range of GA growth rates, ranging from 0.21 to 1.10 disc areas per year, which corresponds to 0.053 to 0.264 mm/year assuming circular lesions with baseline sizes of 3 disc areas.7, 8 In addition, prior authors have come to divergent conclusions on the growth pattern of GA (Table S1).7, 9, 10, 11, 13, 28
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by Research to Prevent Blindness, Inc, New York, New York (principal investigator, L.V.D.P.). The sponsor or funding organization had no role in the design or conduct of this research.
HUMAN SUBJECTS: This is a systematic review article and does not include human subjects.
Author Contributions:
Conception and design: Shen, Del Priore
Analysis and interpretation: Shen, Liu, Del Priore
Data collection: Shen, Liu, Grossetta Nardini, Del Priore
Obtained funding: Del Priore
Overall responsibility: Shen, Liu, Del Priore
Supplemental material available at www.ophthalmologyretina.org.