Original ArticleGlaucoma-like Parapapillary Choroidal Microvasculature Dropout in Patients with Compressive Optic Neuropathy
Section snippets
Participants
Data were obtained retrospectively from patients with CON who had a parasellar tumor and were referred to an ophthalmologic practice for a perioperative ophthalmologic evaluation between March 2016 and August 2018. Data on patients with OAG and on healthy control participants were obtained from the database of the Investigating Glaucoma Progression Study, an ongoing prospective study being performed at the Glaucoma Clinic of Seoul National University Bundang Hospital, Seoul, Republic of Korea.
Results
This study included 88 eyes of 44 patients with CON, 88 eyes of 88 patients with OAG, and 88 eyes of 44 healthy control participants. Of the 44 patients with CON, 29, 8, and 5 were diagnosed with pituitary adenoma, suprasellar meningioma, and craniopharyngioma, respectively. Patients with CON underwent ophthalmic imaging 22.6 ± 27.7 months (range, 6.6–137.2 months) after diagnosis. Choroidal MvD was observed in 30 eyes (34.1%) of 22 patients (50.0%) with CON, unilaterally in 14 patients and
Discussion
Recent studies have identified choroidal MvD in the parapapillary areas of glaucoma patients and have suggested its potential pathogenic relevance with glaucomatous optic neuropathy.15, 16, 17, 18,20,21,33 The present study found that choroidal MvD also was present in some patients with CON, but that the characteristics of choroidal MvD in these eyes differed from those found in glaucomatous eyes. To our knowledge, no previous study has documented the characteristics of parapapillary
References (49)
- et al.
Primary open-angle glaucoma
Lancet
(2004) - et al.
Assessment of optic disk blood flow in patients with open-angle glaucoma
Am J Ophthalmol
(2000) - et al.
Retinal blood flow in glaucomatous eyes with single-hemifield damage
Ophthalmology
(2014) - et al.
Indocyanine green angiography of the peripapillary region in glaucomatous eyes by confocal scanning laser ophthalmoscopy
Am J Ophthalmol
(1997) - et al.
Microvascular density in glaucomatous eyes with hemifield visual field defects: an optical coherence tomography angiography study
Am J Ophthalmol
(2016) - et al.
Deep retinal layer microvasculature dropout detected by the optical coherence tomography angiography in glaucoma
Ophthalmology
(2016) - et al.
Parapapillary choroidal microvasculature dropout in glaucoma: a comparison between optical coherence tomography angiography and indocyanine green angiography
Ophthalmology
(2017) - et al.
Influence of choroidal microvasculature dropout on the rate of glaucomatous progression, a prospective study
Ophthalmol Glaucoma
(2020) - et al.
Differentiation of compressive from glaucomatous optic neuropathy with spectral-domain optical coherence tomography
Ophthalmology
(2014) - et al.
Differentiation of parapapillary atrophy using spectral-domain optical coherence tomography
Ophthalmology
(2013)
Central visual field damage and parapapillary choroidal microvasculature dropout in primary open-angle glaucoma
Ophthalmology
Capillary and mitochondrial support of neural plasticity in adult rat visual cortex
Exp Neurol
Choroidal microvasculature dropout is associated with progressive retinal nerve fiber layer thinning in glaucoma with disc hemorrhage
Ophthalmology
Parapapillary deep-layer microvasculature dropout and visual field progression in glaucoma
Am J Ophthalmol
Projection-resolved optical coherence tomography angiography of the peripapillary retina in glaucoma
Am J Ophthalmol
Projection-resolved optical coherence tomography angiography of macular retinal circulation in glaucoma
Ophthalmology
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma
Arch Ophthalmol
Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial
Arch Ophthalmol
The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration
Am J Ophthalmol
Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures
Am J Ophthalmol
Comparison of colour Doppler imaging and retinal scanning laser fluorescein angiography in healthy volunteers and normal pressure glaucoma patients
Acta Ophthalmol Scand
Optic nerve head blood flow, as measured by laser speckle flowgraphy, is significantly reduced in preperimetric glaucoma
Curr Eye Res
Fluorescein angiography in chronic simple and low-tension glaucoma
Br J Ophthalmol
Peripapillary fluorescein angiographic findings in primary open angle glaucoma
Br J Ophthalmol
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Intereye Comparison of the Characteristics of the Peripapillary Choroid in Patients with Unilateral Normal-Tension Glaucoma
2021, Ophthalmology GlaucomaCitation Excerpt :Alternatively, MvD may be a secondary byproduct of glaucomatous damage. Our recent finding that MvD is present not only in eyes with glaucoma but also in eyes with compressive optic neuropathy51 suggests that MvD may be secondary to an RNFL defect. Because MvD has also been detected in nonglaucomatous healthy eyes,52 MvD should not be considered a simple byproduct in all patients.
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Korean government (Ministry of Education, Science and Technology (grant no.: 2016R1D1A1B02011696). The funder had no role in the design or conduct of this research.
HUMAN SUBJECTS: Human subjects were included in this study. The human ethics committees at Seoul National University Bundang Hospital approved the study. All research adhered to the tenets of the Declaration of Helsinki. Participants in the Investigating Glaucoma Progression Study provided written informed consent to participate.
No animal subjects were included in this study.
Author Contributions:
Conception and design: Lee, T.-W.Kim
Analysis and interpretation: Lee, J.-A.Kim, T.-W.Kim, H.Kim, Yang, Hwang
Data collection: Lee, J.-A.Kim, T.-W.Kim, H.Kim
Obtained funding: N/A
Overall responsibility: Lee, J.-A.Kim, T.-W.Kim, H.Kim, Yang, Hwang