Original articleBruch's Membrane Opening Minimum Rim Width and Retinal Nerve Fiber Layer Thickness in a Normal White Population: A Multicenter Study
Section snippets
Participants
Study participants of self-identified white descent were recruited in 5 centers: 1 in Canada, 2 in the United States, and 2 in Germany. The study was approved by the ethics review board at each institution. In accordance with the Declaration of Helsinki, all subjects gave informed consent to participate.
A verbal screening for participation was conducted first. A medical history then was obtained, followed by an ocular health assessment that included visual acuity measurement with a standard
Results
There were 259 subjects enrolled and tested, of whom 13 (5.0%) were excluded because of poor OCT image quality. Among the remaining 246 subjects, there were approximately 35 to 40 subjects in each decade group, except the group 80 to 89 years of age, which included 14 subjects. The median age was 52.9 years (range, 19.8–87.3 years).
The FoBMO angle varied widely (Fig 3), with a median of −6.7° (range, 2.5° to −17.5°), relative to the horizontal axis of the image frame. The FoBMO angle was
Discussion
Phenotyping the normal ONH and RNFL and constructing accurate normative databases helps the clinician in diagnosing glaucoma. The current study is important because it characterizes for the first time, to the best of our knowledge, indices based on BMO in a normal population acquired and analyzed with respect to the eye-specific orientation of the fovea relative to the ONH.
We confirmed the notable variation in the position of the fovea compared with the ONH16 or BMO center.15 In the current
References (48)
- et al.
Optic disc margin anatomy in patients with glaucoma and normal controls with spectral domain optical coherence tomography
Ophthalmology
(2012) - et al.
From clinical examination of the optic disc to clinical assessment of the optic nerve head: a paradigm change
Am J Ophthalmol
(2013) - et al.
Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography-derived neuroretinal rim parameter
Ophthalmology
(2013) - et al.
Rates of neuroretinal rim and peripapillary atrophy area change: a comparative study of glaucoma patients and normal controls
Ophthalmology
(2009) - et al.
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss
Ophthalmology
(2012) - et al.
Age-related decline of disc rim area in visually normal subjects
Ophthalmology
(1992) - et al.
Scanning laser tomography to evaluate optic discs of normal eyes
Jpn J Ophthalmol
(1999) - et al.
Determinants of optic disc characteristics in a general population: the Rotterdam Study
Ophthalmology
(1999) - et al.
The effect of age on the nerve fiber population of the human optic nerve
Am J Ophthalmol
(1984) - et al.
The normal human optic nerve. Axon count and axon diameter distribution
Ophthalmology
(1989)
A mathematical model for describing the retinal nerve fiber bundle trajectories in the human eye: average course, variability, and influence of refraction, optic disc size and optic disc position
Exp Eye Res
Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography
Ophthalmology
Comparison of the diagnostic capability of the Heidelberg Retina Tomographs 2 and 3 for glaucoma in the Indian population
Ophthalmology
Comparison of clinical and spectral domain optical coherence tomography optic disc margin anatomy
Invest Ophthalmol Vis Sci
Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head
Invest Ophthalmol Vis Sci
A comparison of optic nerve head morphology viewed by spectral domain optical coherence tomography and by serial histology
Invest Ophthalmol Vis Sci
Influence of clinically invisible, but optical coherence tomography detected, optic disc margin anatomy on neuroretinal rim evaluation
Invest Ophthalmol Vis Sci
Minimum distance mapping using three-dimensional optical coherence tomography for glaucoma diagnosis
J Biomed Optics
Spectral domain optical coherence tomography in glaucoma: qualitative and quantitative analysis of the optic nerve head and retinal nerve fiber layer: an AOS thesis
Trans Am Ophthalmol Soc
Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
Invest Ophthalmol Vis Sci
Correlation between optic nerve head structural parameters and glaucomatous visual field indices
Clin Ophthalmol
Structure-function relationships with spectral-domain optical coherence tomography retinal nerve fiber layer and optic nerve head measurements
Invest Ophthalmol Vis Sci
A method to estimate the amount of neuroretinal rim tissue in glaucoma: comparison with current methods for measuring rim area
Am J Ophthalmol
Enhanced structure-function relationship in glaucoma with an anatomically and geometrically accurate neuroretinal rim measurement
Invest Ophthalmol Vis Sci
Cited by (0)
Supplemental material is available at www.aaojournal.org.
Financial Disclosure(s): The author(s) have made the following disclosure(s):
B.C.C.: Financial support - Heidelberg Engineering GmbH, Heidelberg, Germany
S.D.: Financial support - Heidelberg Engineering GmbH, Heidelberg, Germany
C.A.G.: Financial support - Heidelberg Engineering GmbH, Heidelberg, Germany
C.Y.M.: Financial support - Heidelberg Engineering GmbH, Heidelberg, Germany
A.F.S.: Financial support - Heidelberg Engineering GmbH, Heidelberg, Germany
C.F.B.: Financial support - Heidelberg Engineering GmbH, Heidelberg, Germany
Supported by the Canadian Institutes of Health Research, Ottawa, Ontario (grant no.: MOP11357 [B.C.C.]), National Eye Institute, National Institutes of Health, Bethesda, MD (grant no. EY021281 [C.F.B.]); and the Center for Disease Control, Atlanta, GA (C.A.G.).
Author Contributions:
Conception and design: Chauhan, Burgoyne
Analysis and interpretation: Chauhan, Danthurebandara, Burgoyne
Data collection: Chauhan, Sharpe, Demirel, Girkin, Mardin, Scheuerle,
Obtained funding: Chauhan
Overall responsibility: Chauhan