Original articleCorneal High-Order Aberrations and Backscatter in Fuchs' Endothelial Corneal Dystrophy
Section snippets
Subjects and Clinical Grading
All subjects were examined by cornea specialists using slit-lamp biomicroscopy. Severity of FECD was graded clinically on the basis of the area and confluence of guttae, and the presence of edema, as described previously.15, 16 Corneas with 1 to 12 or ≥12 nonconfluent central guttae (grades 1 and 2) were considered to have mild FECD; corneas with confluent guttae of 1- to 2-mm and 2- to 5-mm diameter (grades 3 and 4) were considered to have moderate FECD, and corneas with >5-mm diameter of
Subjects
A total of 108 corneas from 62 subjects with FECD and 71 normal corneas from 38 subjects were examined; the median age was 66 years (range, 40–89 years) (Table 1). Subjects with FECD were older than controls (mean difference, 7.9 years; P = 0.002). Subjects with mild (P = 0.01) and moderate (P = 0.03) FECD were more often pseudophakic than controls.
Corneal High-Order Aberrations
Data from 1 eye with FECD were excluded from analysis because of acquisition errors. Anterior corneal total HOAs were increased in moderate (P =
Discussion
Anterior corneal HOAs were increased in moderate and advanced FECD compared with controls, before clinically visible corneal edema, and posterior corneal HOAs and corneal backscatter were increased even in mild FECD. Increased posterior corneal HOAs and anterior and posterior corneal backscatter were associated with lower ECDe and thicker corneas in FECD. These data indicate that surface changes occur earlier than previously thought.
Increased anterior corneal HOAs in advanced FECD (with corneal
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by Research to Prevent Blindness, New York, New York (unrestricted grant to the Department of Ophthalmology and support (to S.V.P.) as Olga Keith Wiess Special Scholar); Dr. Werner Jackstaedt-Stiftung, Wuppertal, Germany (Research Fellowship to K.W.); Mayo Clinic Center for Translational Science Activities (grant no. UL1 TR000135 from the National Center for Advancing Translational Sciences, a component of the National Institutes of Health, Bethesda, MD); and Mayo Foundation, Rochester, Minnesota. The funding organizations had no role in the design or conduct of this research.
Author Contributions:
Conception and design: Wacker, McLaren, Amin, Baratz, Patel
Data collection: Wacker, Amin, Patel
Analysis and interpretation: Wacker, McLaren, Amin, Baratz, Patel
Obtained funding: Not applicable
Overall responsibility: Wacker, McLaren, Amin, Baratz, Patel