Original ArticleSubthreshold Grid Laser Treatment of Macular Edema Secondary to Branch Retinal Vein Occlusion with Micropulse Infrared (810 Nanometer) Diode Laser
Section snippets
Materials and Methods
A prospective randomized clinical pilot trial was planned to compare the effects of SGLT performed by infrared micropulse diode laser and of TGLT delivered with krypton laser. Patients affected by BRVO observed in the outpatient department of Trieste Eye Clinic between June 2001 and December 2002 were identified and invited to enroll prospectively. The research adhered to the tenets of the Declaration of Helsinki, and investigational review board approval was obtained. Each patient was
Results
Forty-four patients with macular edema secondary to BRVO were considered for the study. Three of them were excluded from the study because they had undergone previous photocoagulation, and 5 patients declined to take part in the study. No patient showed sensory retinal detachment on OCT, either at baseline or over the follow-up. Overall, 36 patients (36 eyes) fulfilling the inclusion and exclusion criteria were randomized either to SGLT (17 eyes) or to TGLT (19 eyes).
Complete demographic
Discussion
The Branch Vein Occlusion Study Group has demonstrated that grid laser treatment performed using argon laser is effective both in promoting macular edema resolution and in improving VA.2 Unfortunately, conventional grid laser treatment delivered with a visible ophthalmoscopic end point may bring about several complications over the long-term follow-up (i.e., scar enlargement, subretinal fibrosis, choroidal neovascularization, and perimetric sensitivity deterioration) that can severely affect
References (37)
- et al.
Atrophic creep of the retinal pigment epithelium after focal macular photocoagulation
Ophthalmology
(1989) - et al.
Submacular fibrosis after photocoagulation for diabetic macular edema
Am J Ophthalmol
(1992) - et al.
Modified grid laser photocoagulation for diabetic macular edema: the effect on the central visual field
Ophthalmology
(1988) - et al.
The treatment of macular disease using a micropulsed and continuous wave 810-nm diode laser
Ophthalmology
(1997) - et al.
The effects of red krypton and green argon laser on the foveal region: a clinical and experimental study
Ophthalmology
(1983) - et al.
Macular oedema and retinal branch vein occlusion
Aust J Ophthalmol
(1980) Argon laser photocoagulation for macular edema in branch vein occlusion
Am J Ophthalmol
(1984)- et al.
Progressive enlargement of laser scars following grid laser photocoagulation for diffuse diabetic macular edema
Arch Ophthalmol
(1991) Focal photocoagulation treatment of diabetic macular edemaRelationship of treatment effect to fluorescein angiographic and other retinal characteristics at baseline: ETDRS report no 19
Arch Ophthalmol
(1995)Subretinal neovascularization complicating laser photocoagulation of diabetic maculopathy
Ophthalmic Surg
(1988)
Choroidal neovascularization after laser photocoagulation for diabetic macular edema
Ophthalmology
Subretinal fibrosis after laser photocoagulation for diabetic macular edema
Am J Ophthalmol
Sub-pigment epithelial membranes after photocoagulation for diabetic macular edema
Arch Ophthalmol
Subretinal fibrosis in diabetic macular edemaETDRS report 23
Arch Ophthalmol
Influence of laser photocoagulation for clinically significant diabetic macular oedema (DMO) on short-wavelength and conventional automated perimetry
Diabetologia
Short-wavelength sensitive visual field loss in patients with clinically significant diabetic macular oedema
Diabetologia
The use of scanning laser ophthalmoscope microperimetry to detect visual impairment caused by macular photocoagulation
Ophthalmic Surg Lasers
Automatic static threshold perimetry is useful for estimating the effects of laser photocoagulation on diabetic maculopathy
Ophthalmic Res
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2021, Progress in Retinal and Eye ResearchCitation Excerpt :Friberg and Karatza (1997) in 14 BRVO eyes reported resolution of macular edema by 6 months in 92% of eyes, and 77% had stabilization of visual acuity. A study (Parodi et al., 2006) comparing the effectiveness of subthreshold grid laser treatment with an infrared micropulse diode laser with that of threshold grid laser treatment for macular edema secondary to BRVO found that resolution of macular edema and visual acuity improvement are similar to those obtained with conventional threshold grid laser treatment, but subthreshold grid laser treatment with an infrared micropulse diode laser is not associated with biomicroscopic and angiographic signs. Luttrull et al., (2012) also reported resolution of macular edema with this laser treatment.
Manuscript no. 2005-921.