Oral and maxillofacial pathology
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Congenital granular cell lesion of the tongue: a report of two cases and review of the literature

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The congenital granular cell lesion most commonly occurs on the maxillary or mandibular alveolus of neonates. Extra-alveolar congenital granular cell lesion is exceptionally rare, with only 10 cases reported. Two additional cases occurring on the tongue are presented with a description of the clinical, histopathologic, and immunohistochemical features. The differential diagnosis is discussed, and the literature reviewed.

Section snippets

Case 1

The oral and maxillofacial surgery service at Long Island Jewish Medical Center was consulted by neonatal medicine to evaluate a large soft tissue lesion on the tongue of a 2-day-old female. She was born with no complications at full term by vaginal delivery. Her mother was in good health with no significant medical history and had had an uneventful pregnancy. The patient's mother reported interference with regular feeding related to the lesion. On clinical examination, the child was in no

Discussion

The CGCL most commonly occurs on the maxillary alveolar process of female infants.1, 2 It can be confused with a granular cell tumor (GCT), which has some overlapping histopathologic features but is a separate and distinct clinicopathologic entity.1, 2, 7 The GCT occurs in adults, most commonly on the tongue as a submucosal nodule.2, 12 Microscopic evaluation of the GCT demonstrates a thickened surface epithelium that may show pseudoepitheliomatous hyperplasia (PEH).2, 12 This is in contrast to

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