Original ArticleNovel protection by Omega-3-FAs (DHA or EPA) against carbamazepine's liver-injury: differential suppression of oxidative-stress and inflammatory markers, and the influence on carbamazepine-clearance
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Graphical abstract
Whether, and how/mechanisms, the ω-3-FAs ameliorate carbamazepine (CBZ)'s liver-injury, remained unknown. Both FAs significantly-alleviated CBZ-insult; ranked, DHA > EPA, and significantly-suppressed CBZ-elevated markers of liver biochemistry, oxidative-stress, and inflammation. DHA showed no pharmacokinetic-interaction with plasma-CBZ, while EPA raised CBZ-plasma-levels. Histopathologic-analysis confirmed the remedial-DHA/EPA responses.
Keywords
Carbamazepine
Omega-3-FAs
Cytokines
Oxidative-stress
Clearance
Liver-injury
Abbreviations
CBZ
Carbamazepine
ω-3-FAs
Omega-3-fatty-acids
EPA
Eicosapentaenoic acid
DHA
Docosahexaenoic acid
ALP
Alkaline-phosphatase
γ-GT
Gamma-glutamyl-transferase
TNF-α
Tumor-necrosis-factor-α
CRP
C-reactive-protein
GSH
Reduced-glutathione
MDA
Malondialdehyde
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© 2022 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism.