Elsevier

Nutrition

Volume 28, Issue 5, May 2012, Pages 544-550
Nutrition

Applied nutritional investigation
Triacylglycerols and body fat mass are possible independent predictors of C3 in apparently healthy young Brazilian adults

https://doi.org/10.1016/j.nut.2011.08.014Get rights and content
Under an Elsevier user license
open access

Abstract

Objective

To evaluate the association between serum concentrations of complement factor-3 (C3) with anthropometric, biochemical, and lifestyle features in healthy young adults.

Methods

From 157 young healthy adults 18 to 35 y old, anthropometric measurements and body composition, systolic and diastolic blood pressures, and lifestyle data were collected and analyzed. Blood samples were collected after a 12-h fast for the determination of glucose, triacylglycerols, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, insulin, C3, ceruloplasmin, and uric acid.

Results

Complement factor-3 correlated directly with body mass index (r = 0.23417, P = 0.0032), body fat mass (bioelectrical impedance analysis; r = 0.33407, P < 0.0001), percentage of body fat (bioelectrical impedance analysis; r = 0.26873, P = 0.0007), waist circumference (r = 0.21266, P = 0.0075), insulin (r = 0.26152, P = 0.0009), homeostasis model assessment of insulin resistance (r = 0.24831, P = 0.0017), total cholesterol (r = 0.23335, P = 0.0033), triacylglycerols (r = 0.38435, P < 0.0001), and other outcome measurements. In the multiple linear regression analysis, triacylglycerols (r2 = 0.1379, P < 0.0001) and body fat mass (bioelectrical impedance analysis; r2 = 0.0621, P = 0.0010) were independently associated with the C3 concentration after adjusting for age, gender, smoking status, and physical activity.

Conclusion

Complement factor-3 seems to be related to several anthropometric and biochemical measurements in healthy young adults. These results demonstrate an independent role of triacylglycerols, a component of the metabolic syndrome, and body fat mass as possible predictors of C3 concentrations. Thus, C3 can be used as an early marker for metabolic syndrome manifestations.

Keywords

Complement factor-3
Body composition
Obesity
Lifestyle
Inflammation
Metabolic syndrome
Triacylglycerols

Cited by (0)

This work was supported by scholarships from the Coordination for the Improvement of Higher Education of the Ministry of Education of Brazil and a grant from the Foundation for Research Support of Minas Gerais proposal (CDS 303/06).