21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans
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A Q & A with Jeff and Dick
Jeff Watkins writes: I have not really kept up with developments in the field since my retirement. I would be particularly interested if any answers have been found to the following questions:
- 1.
Is l-aspartate (or, even more importantly, D-aspartate*) rather than l-glutamate, the actual transmitter, at least at some NMDA receptors (e.g., in the ventral horn of the spinal cord)? Has anyone investigated the relative affinity of l-aspartate-plus-glycine (or D-aspartate plus glycine or, yet more
References (140)
- et al.
NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII
Neuron
(2005) - et al.
Antidepressant effects of ketamine in depressed patients
Biol. Psychiatr.
(2000) - et al.
NMDA receptor function in inhibitory neurons
Neuropharmacology
(2021) - et al.
Towards resolving the presynaptic NMDA receptor debate
Curr. Opin. Neurobiol.
(2018) - et al.
Glutamate is a positive autocrine signal for glucagon release
Cell Metabol.
(2008) - et al.
Brain-derived neurotrophic factor signaling in depression and antidepressant action
Biol. Psychiatr.
(2021) - et al.
Antidepressant actions of ketamine versus hydroxynorketamine
Biol. Psychiatr.
(2017) - et al.
Domoic acid as a developmental neurotoxin
Neurotoxicology
(2010) - et al.
LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs
Eur. J. Pharmacol.
(1998) - et al.
Evolutionary insight into the ionotropic glutamate receptor superfamily of photosynthetic organisms
Biophys. Chem.
(2016)
Metabotropic glutamate receptors: modulators of context-dependent feeding behaviour in C. elegans
J. Biol. Chem.
(2015)
Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1
Eur. J. Pharmacol.
(2008)
Characterization of the two distinct subtypes of metabotropic glutamate receptors from honeybee, Apis mellifera
Neurosci. Lett.
(2004)
AlphaCaMKII binding to the C-terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation
FEBS Lett.
(1999)
NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A
Brain Res Mol Brain Res
(1999)
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo
Neuron
(2011)
Positive allosteric modulators of GluN2A-containing NMDARs with distinct modes of action and impacts on circuit function
Neuron
(2016)
Distinct functional and pharmacological properties of triheteromeric GluN1/GluN2A/GluN2B NMDA receptors
Neuron
(2014)
Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial
Lancet
(2020)
Direct presynaptic regulation of GABA/glycine release by kainate receptors in the dorsal horn: an ionotropic mechanism
Neuron
(2001)
Synapse-specific control of experience-dependent plasticity by presynaptic NMDA receptors
Neuron
(2014)
Novel functional properties of Drosophila CNS glutamate receptors
Neuron
(2016)
LTP and LTD: an embarrassment of riches
Neuron
(2004)
Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization
Neuron
(2000)
Identification of functional ionotropic glutamate receptor proteins in pancreatic beta-cells and in islets of Langerhans
FEBS Lett.
(1995)
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
Neuron
(1994)
Molecular mechanisms of glutamate receptor clustering at excitatory synapses
Curr. Opin. Neurobiol.
(1998)
Exciting times for pancreatic islets: glutamate signaling in endocrine cells
Trends Endocrinol. Metabol.
(2016)
Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes
Proc. Natl. Acad. Sci. U. S. A.
(2015)
Presynaptic spike timing-dependent long-term depression in the mouse Hippocampus
Cerebr. Cortex
(2016)
Schaffer collateral and perforant path inputs activate different subtypes of NMDA receptors on the same CA1 pyramidal cell
Br. J. Pharmacol.
(2004)
Discovery and development of NA-1 for the treatment of acute ischemic stroke
Acta Pharmacol. Sin.
(2018)
Distinct mechanisms of spike timing-dependent LTD at vertical and horizontal inputs onto L2/3 pyramidal neurons in mouse barrel cortex
Phys. Rep.
(2014)
Double dissociation of spike timing-dependent potentiation and depression by subunit-preferring NMDA receptor antagonists in mouse barrel cortex
Cerebr. Cortex
(2009)
Interaction with the NMDA receptor locks CaMKII in an active conformation
Nature
(2001)
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex
J. Neurosci.
(2006)
The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression
BMC Genom.
(2014)
Triheteromeric GluN1/GluN2A/GluN2C NMDARs with unique single-channel properties are the dominant receptor population in cerebellar granule cells
Neuron
(2018)
Contribution of NMDA receptors to synaptic function in rat hippocampal interneurons
eneuro
(2021)
Modulation of central synapses by astrocyte-released ATP and postsynaptic P2X receptors
Neural Plast.
(2017)
Epigenomic plasticity enables human pancreatic α to β cell reprogramming
J. Clin. Invest.
(2013)
Nucleus accumbens long-term depression and the expression of behavioral sensitization
Science
(2005)
Metabotropic glutamate and GABA(B) receptors contribute to the modulation of glucose-stimulated insulin secretion in pancreatic beta cells
Diabetologia
(2002)
Ionotropic glutamate receptors: genetics, behavior and electrophysiology
Worm
(2006)
NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones
J. Physiol.
(2008)
Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex
Proc. Natl. Acad. Sci. U. S. A.
(2004)
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes
J. Physiol.
(2008)
Characteristics and functions of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors expressed in mouse pancreatic {alpha}-cells
Endocrinology
(2010)
Structural basis of functional transitions in mammalian NMDA receptors
Cell
(2020)
Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression
J. Neurosci.
(2007)
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