Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells
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Keywords
Neuroinflammation
Autoimmunity
mGluR4
Noncanonical GPCR signaling
PI3K
Src kinase
Tryptophan metabolism
Indoleamine 2,3-dioxygenase 1
Dendritic cells
Immune regulation
Abbreviations
DC
Dendritic cell
IDO1
indoleamine 2,3-dioxygenase 1
ITIM
immunoreceptor tyrosine-based inhibitory motif
mGluR
metabotropic glutamate receptor
PAM
positive allosteric modulator
PI3K
phosphatidylinositol-3-kinase
RR-EAE
relapsing-remitting experimental autoimmune encephalomyelitis
Treg
T regulatory
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Copyright © 2015 The Authors. Published by Elsevier Ltd.