Neuron
Volume 71, Issue 4, 25 August 2011, Pages 695-709
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Article
Pioneer GABA Cells Comprise a Subpopulation of Hub Neurons in the Developing Hippocampus

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Summary

Connectivity in the developing hippocampus displays a functional organization particularly effective in supporting network synchronization, as it includes superconnected hub neurons. We have previously shown that hub network function is supported by a subpopulation of GABA neurons. However, it is unclear whether hub cells are only transiently present or later develop into distinctive subclasses of interneurons. These questions are difficult to assess given the heterogeneity of the GABA neurons and the poor early expression of markers. To circumvent this conundrum, we used “genetic fate mapping” that allows for the selective labeling of GABA neurons based on their place and time of origin. We show that early-generated GABA cells form a subpopulation of hub neurons, characterized by an exceptionally widespread axonal arborization and the ability to single-handedly impact network dynamics when stimulated. Pioneer hub neurons remain into adulthood, when they acquire the classical markers of long-range projecting GABA neurons.

Highlights

► Early-generated GABA neurons display a hub network function ► Stimulation of a single early-generated GABA neuron alters network synchrony in the developing hippocampus ► Early-generated GABA neurons acquire characteristics of GABA projection neurons

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